Human Recombinant GMPR protein, His Tag (V2LY-0526-LY4368)

Name: Human Recombinant GMPR protein, His Tag
SKU: V2LY-0526-LY4368
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant GMPR protein, His Tag consist of Amino Acid: 1-345 and predicts a molecular mass of 39.2 kDa.

Molecule Mass

39.2 kDa

Sequence

Amino Acid: 1-345

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Guanosine Monophosphate Reductase

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Biological Process

Purine nucleobase metabolic process Source: UniProtKB-KW
Purine nucleotide metabolic process Source: UniProtKB-UniRule
Response to cold Source: ProtInc

Cellular Location

Cytosol; GMP reductase complex

Gaiya, D. D., Muhammad, A., Aimola, I. A., Udu, S. K., Balarabe, S. A., Auta, R., ... & Sheyin, A. (2023). Potential of Onchocerca ochengi inosine-5′-monophosphate dehydrogenase (IMPDH) and guanosine-5′-monophosphate oxidoreductase (GMPR) as druggable and vaccine candidates: immunoinformatics screening. Journal of Biomolecular Structure and Dynamics, 1-17.

Wolff, D. W., Deng, Z., Bianchi-Smiraglia, A., Foley, C. E., Han, Z., Wang, X., ... & Nikiforov, M. A. (2022). Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro-to anti-oncogenic function of EPHA4. Cell Chemical Biology, 29(6), 970-984.

Knejzlík, Z., Doležal, M., Herkommerová, K., Clarova, K., Klíma, M., Dedola, M., ... & Pichová, I. (2022). The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain. The FEBS Journal, 289(18), 5571-5598.

Sommerville, E. W., Dalla Rosa, I., Rosenberg, M. M., Bruni, F., Thompson, K., Rocha, M., ... & Gorman, G. S. (2020). Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late‐onset disorder of mitochondrial DNA maintenance. Clinical Genetics, 97(2), 276-286.

Bairagya, H. R., Tasneem, A., Rai, G. P., & Reyaz, S. (2020). Structural and dynamical impact of water molecules at substrate-or product-binding sites in human GMPR enzyme: a study by molecular dynamics simulations. The Journal of Physical Chemistry B, 125(5), 1351-1362.

Rosenberg, M. M., Redfield, A. G., Roberts, M. F., & Hedstrom, L. (2018). Dynamic Characteristics of Guanosine-5′-monophosphate Reductase Complexes Revealed by High-Resolution 31P Field-Cycling NMR Relaxometry. Biochemistry, 57(22), 3146-3154.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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