Mouse Anti-GMPR Recombinant Antibody (3G12) (V2LY-0226-LY102)

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Basic Information

Host Animal
Mouse
Clone
3G12
Application
WB
Immunogen
Full length human recombinant protein of human GMPR.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Guanosine Monophosphate Reductase
Entrez Gene ID
UniProt ID
Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Biological Process
Purine nucleobase metabolic process Source: UniProtKB-KW
Purine nucleotide metabolic process Source: UniProtKB-UniRule
Response to cold Source: ProtInc
Cellular Location
Cytosol; GMP reductase complex

Gaiya, D. D., Muhammad, A., Aimola, I. A., Udu, S. K., Balarabe, S. A., Auta, R., ... & Sheyin, A. (2023). Potential of Onchocerca ochengi inosine-5′-monophosphate dehydrogenase (IMPDH) and guanosine-5′-monophosphate oxidoreductase (GMPR) as druggable and vaccine candidates: immunoinformatics screening. Journal of Biomolecular Structure and Dynamics, 1-17.

Wolff, D. W., Deng, Z., Bianchi-Smiraglia, A., Foley, C. E., Han, Z., Wang, X., ... & Nikiforov, M. A. (2022). Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro-to anti-oncogenic function of EPHA4. Cell Chemical Biology, 29(6), 970-984.

Knejzlík, Z., Doležal, M., Herkommerová, K., Clarova, K., Klíma, M., Dedola, M., ... & Pichová, I. (2022). The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain. The FEBS Journal, 289(18), 5571-5598.

Sommerville, E. W., Dalla Rosa, I., Rosenberg, M. M., Bruni, F., Thompson, K., Rocha, M., ... & Gorman, G. S. (2020). Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late‐onset disorder of mitochondrial DNA maintenance. Clinical Genetics, 97(2), 276-286.

Bairagya, H. R., Tasneem, A., Rai, G. P., & Reyaz, S. (2020). Structural and dynamical impact of water molecules at substrate-or product-binding sites in human GMPR enzyme: a study by molecular dynamics simulations. The Journal of Physical Chemistry B, 125(5), 1351-1362.

Rosenberg, M. M., Redfield, A. G., Roberts, M. F., & Hedstrom, L. (2018). Dynamic Characteristics of Guanosine-5′-monophosphate Reductase Complexes Revealed by High-Resolution 31P Field-Cycling NMR Relaxometry. Biochemistry, 57(22), 3146-3154.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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