Human Recombinant GRB2 protein, SH3-2 Domain, GST Tag (V2LY-0526-LY4410)

Name: Human Recombinant GRB2 protein, SH3-2 Domain, GST Tag
SKU: V2LY-0526-LY4410
Rating: 5 (1 reviews)

See all GRB2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant GRB2 protein, SH3-2 Domain, GST Tag consist of Amino Acid: 153-end and predicts a molecular mass of 33 kDa.

Molecule Mass

33 kDa

Protein Domain

SH3-2 Domain

Sequence

Amino Acid: 153-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

growth factor receptor bound protein 2

Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Isoform 2:
Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Aging Source: Ensembl
Anatomical structure formation involved in morphogenesis Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Cell differentiation Source: Ensembl
Cellular response to ionizing radiation Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Insulin receptor signaling pathway Source: UniProtKB
Positive regulation of actin filament polymerization Source: Ensembl
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Ras protein signal transduction Source: UniProtKB
Receptor internalization Source: BHF-UCL
Regulation of MAPK cascade Source: Ensembl
Signal transduction in response to DNA damage Source: BHF-UCL

Cellular Location

Endosome; Golgi apparatus; Cytoplasm; Nucleus

Chang, S. Y., Han, S. Z., Choe, H. M., Gao, K., Jin, Z. Y., Liu, X. Y., ... & Kang, J. D. (2022). miR-320 regulates myogenesis by targeting growth factor receptor-bound protein-2 and ameliorates myotubes atrophy. The International Journal of Biochemistry & Cell Biology, 147, 106212.

Yu, Z., Xu, Y., Du, L., Zhang, F., Shao, M., Xie, L., ... & Lyu, F. (2022). Synergistic effect of growth factor receptor-bound protein 2/epidermal growth factor receptor dual-targeting peptide inhibitor and salinomycin on osteosarcoma. Journal of Cancer Research and Therapeutics, 18(2), 352-361.

Liao, Q., & Gao, X. (2022). Tribbles homolog 3 contributes to high glucose-induced injury in retinal pigment epithelial cells via binding to growth factor receptor-bound 2. Bioengineered, 13(4), 10386-10398.

Lara, O. D., Rodriguez-Aguayo, C., Bayraktar, E., Amero, P., Ma, S., Mangala, L. S., ... & Sood, A. K. (2020). A needle in a haystack: Targeting growth factor receptor bound protein-2 (Grb2) as a novel therapeutic in uterine carcinoma. Gynecologic Oncology, 159, 229-230.

Lewis, T. R., Smith, J., Griffin, K., Aguiar, S., Rueb, K. F., Holmberg-Douglas, N., ... & Arpin, C. C. (2020). NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferation. Plos one, 15(8), e0236839.

Zhao, X. R., Zhang, Z., Gao, M., Li, L., Sun, P. Y., Xu, L. N., ... & Peng, J. Y. (2020). MicroRNA-27a-3p aggravates renal ischemia/reperfusion injury by promoting oxidative stress via targeting growth factor receptor-bound protein 2. Pharmacological Research, 155, 104718.

Bolgov, A., Korban, S., Luzik, D., Zhemkov, V., Kim, M., Rogacheva, O., & Bezprozvanny, I. (2020). Crystal structure of the SH3 domain of growth factor receptor-bound protein 2. Acta Crystallographica Section F: Structural Biology Communications, 76(6), 263-270.

Li, C., Bademci, G., Subasioglu, A., Diaz-Horta, O., Zhu, Y., Liu, J., ... & Tekin, M. (2019). Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. Proceedings of the National Academy of Sciences, 116(4), 1347-1352.

Fares, M., Mohamed, H. T., Ibrahim, S. A., Hosney, M., Rady, M. I., El-Shinawi, M., & Mohamed, M. M. (2019). Incidence of human cytomegalovirus in breast carcinoma tissues is associated with a higher expression of growth factor receptor-bound protein 2. The Egyptian Journal of Hospital Medicine, 75(3), 2358-2365.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant GRB2 protein, SH3-2 Domain, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant GRB2 protein, GST Tag (CAT#: V2LY-0526-LY4408)

Human Recombinant GRB2 protein, SH3-1 Domain, GST Tag (CAT#: V2LY-0526-LY4409)

Related Products

Mouse Anti-GRB2 Recombinant Antibody (CBFYH-0470) (CAT#: V2LY-0226-LY1054)

Rabbit Anti-GRB2 Recombinant Antibody (
6E1) (CAT#: V2LY-0725-LY1563)

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1701) (CAT#: CBMAB-G4808-LY)

Mouse Anti-GRB2 Recombinant Antibody (3F2) (CAT#: CBMAB-G4795-LY)

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1699) (CAT#: CBMAB-G4806-LY)

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1702) (CAT#: CBMAB-G4809-LY)

Human Recombinant GRB2 protein, SH3-1 Domain, GST Tag (CAT#: V2LY-0526-LY4409)

Mouse Anti-GRB2 Recombinant Antibody (5G1) (CAT#: CBMAB-G4799-LY)

Rabbit Anti-GRB2 Recombinant Antibody (37) (CAT#: CBMAB-G0757-LY)

Human Recombinant GRB2 protein, GST Tag (CAT#: V2LY-0526-LY4408)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry