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GRB2

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

growth factor receptor bound protein 2

Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Isoform 2:
Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Aging Source: Ensembl
Anatomical structure formation involved in morphogenesis Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Cell differentiation Source: Ensembl
Cellular response to ionizing radiation Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Insulin receptor signaling pathway Source: UniProtKB
Positive regulation of actin filament polymerization Source: Ensembl
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Ras protein signal transduction Source: UniProtKB
Receptor internalization Source: BHF-UCL
Regulation of MAPK cascade Source: Ensembl
Signal transduction in response to DNA damage Source: BHF-UCL

Cellular Location

Endosome; Golgi apparatus; Cytoplasm; Nucleus

Anti-GRB2 antibodies

Rabbit Anti-GRB2 Antibody (6BA29) (CBMAB-1298CQ)

SDS

Target: GRB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 6BA29

Application*: E, WB

Mouse Anti-GRB2 (AA 1-217) Recombinant Antibody (CBFYH-0470) (CBMAB-H1342-FY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBFYH-0470

Application*: WB

Rabbit Anti-GRB2 Recombinant Antibody (EG1432) (CBMAB-EN1711-LY)

SDS

Target: GRB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1432

Application*: WB: 1:500~1:3000 ELISA: 1:40000

Mouse Anti-GRB2 Recombinant Antibody (CAP855) (CBMAB-AP2601LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: CAP855

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CAP854) (CBMAB-AP2600LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP854

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CB58A) (CBMAB-CA058LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse, Monkey

Clone: CB58A

Application*: ELISA, WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1712) (CBMAB-G4819-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1712

Application*: IP

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1711) (CBMAB-G4818-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: CBLG1-1711

Application*: P, WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1710) (CBMAB-G4817-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBLG1-1710

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1709) (CBMAB-G4816-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1709

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1708) (CBMAB-G4815-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1708

Application*: IP

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1706) (CBMAB-G4813-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-1706

Application*: IF, C, P, WB

Mouse Anti-GRB2 Recombinant Antibody (2GB04) (CBMAB-G0753-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2GB04

Application*: IF, P

Mouse Anti-GRB2 Recombinant Antibody (3B2-G2-E5) (CBMAB-G0754-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse, Monkey

Clone: 3B2-G2-E5

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (669604) (CBMAB-G0755-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 669604

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-2942) (CBMAB-G0756-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Chicken, Dog, Frog, Human, Mouse

Clone: CBLG1-2942

Application*: WB

Rabbit Anti-GRB2 Recombinant Antibody (Y237) (CBMAB-G0757-LY)

SDS

Target: GRB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: Y237

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-217) (CBMAB-G0758-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-217

Application*: IF, WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-218) (CBMAB-G0759-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-218

Application*: E, IF, IH

Mouse Anti-GRB2 Recombinant Antibody (0.T.53) (CBMAB-G4789-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat, Cattle, Human, Mouse

Clone: 0.T.53

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (0-T-53) (CBMAB-G4790-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: 0-T-53

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (13k59) (CBMAB-G4791-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse, Rat

Clone: 13k59

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (2B2.23) (CBMAB-G4793-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Cattle, Mouse, Rat, Frog

Clone: 2B2.23

Application*: IF, WB

Mouse Anti-GRB2 Recombinant Antibody (2GB04C1.4) (CBMAB-G4794-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Cattle, Mouse, Rat, Frog

Clone: 2GB04C1.4

Application*: IF, P

Mouse Anti-GRB2 Recombinant Antibody (3F2) (CBMAB-G4795-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 3F2

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (3H2183) (CBMAB-G4796-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3H2183

Application*: IP

Mouse Anti-GRB2 Recombinant Antibody (4C6-H6) (CBMAB-G4798-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: 4C6-H6

Application*: E, WB

Mouse Anti-GRB2 Recombinant Antibody (5G121) (CBMAB-G4799-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Cattle, Mouse, Rat, Frog

Clone: 5G121

Application*: E, IF, IH

Mouse Anti-GRB2 Recombinant Antibody (C1-4) (CBMAB-G4801-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: C1-4

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (GRB-232) (CBMAB-G4802-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG3

Specificity: Mouse, Rat, Human

Clone: GRB-232

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (M331) (CBMAB-G4803-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Human

Clone: M331

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (R11) (CBMAB-G4804-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: R11

Application*: WB

Rabbit Anti-GRB2 Recombinant Antibody (Y301) (CBMAB-G4805-LY)

SDS

Target: GRB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: Y301

Application*: WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1699) (CBMAB-G4806-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1699

Application*: IP, WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1701) (CBMAB-G4808-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-1701

Application*: IF, C, P, WB

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1702) (CBMAB-G4809-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-1702

Application*: C, P

Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1705) (CBMAB-G4812-LY)

SDS

Target: GRB2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1705

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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