Human Recombinant IL12A protein, hFc Tag (V2LY-0526-LY4723)

Name: Human Recombinant IL12A protein, hFc Tag
SKU: V2LY-0526-LY4723
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant IL12A protein, hFc Tag consist of Amino Acid: 1-219 and predicts a molecular mass of 49.3 kDa.

Molecule Mass

49.3 kDa

Sequence

Amino Acid: 1-219

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 12A

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Biological Process

Cell migration Source: UniProtKB
Cellular response to virus Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Immune response Source: UniProtKB
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: ARUK-UCL
Negative regulation of interleukin-17 production Source: BHF-UCL
Negative regulation of protein secretion Source: ARUK-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Negative regulation of vascular endothelial growth factor signaling pathway Source: ARUK-UCL
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of dendritic cell chemotaxis Source: UniProtKB
Positive regulation of interferon-gamma production Source: ComplexPortal
Positive regulation of lymphocyte proliferation Source: UniProtKB
Positive regulation of mononuclear cell proliferation Source: AgBase
Positive regulation of natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: UniProtKB
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell activation Source: BHF-UCL
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of smooth muscle cell apoptotic process Source: BHF-UCL
Positive regulation of T cell mediated cytotoxicity Source: UniProtKB
Positive regulation of T cell proliferation Source: ComplexPortal
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
Response to UV-B Source: UniProtKB
Response to virus Source: UniProtKB

Cellular Location

Secreted

Mohsen, R. T., Al-Azzawi, R. H., & Ad’hiah, A. H. (2022). A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients. Egyptian Journal of Medical Human Genetics, 23(1), 1-3.

Wang, Z., Liu, M., Ye, D., Ye, J., Wang, M., Liu, J., ... & Wan, J. (2021). Il12a deletion aggravates sepsis-induced cardiac dysfunction by regulating macrophage polarization. Frontiers in Pharmacology, 12, 632912.

Nasser Dhabaan, A. A., & Mahdi, M. A. H. (2020). Association between IL12A Gene of G/A genotype Polymorphism and Pulmonary Tuberculosis Risk in Baghdad Population. Indian Journal of Forensic Medicine & Toxicology, 14(3).

Yu, C. R., Choi, J. K., Uche, A. N., & Egwuagu, C. E. (2018). Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements. Journal of Leukocyte Biology, 104(6), 1147-1157.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL12A protein (CAT#: V2LY-0526-LY1546)

Human Recombinant IL12A protein, His Tag (CAT#: V2LY-0526-LY4724)

Human Recombinant IL12A protein, His Tag-1 (CAT#: V2LY-0526-LY4727)

Human Recombinant IL12A protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4728)

Human Recombinant IL12A protein, His Tag-2 (CAT#: V2LY-0526-LY4730)

Human Recombinant IL12A protein (CAT#: V2LY-0526-LY4731)

Human Recombinant IL12A protein-1 (CAT#: V2LY-0526-LY4732)

Mouse Recombinant IL12A protein, hFc Tag (CAT#: V2LY-0526-LY8468)

Mouse Recombinant IL12A protein, His & hFc Tag (CAT#: V2LY-0526-LY8469)

Mouse Recombinant IL12A protein, His & hFc Tag-1 (CAT#: V2LY-0526-LY8470)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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