Il12a

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Interleukin 12A

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Cell migration Source: UniProtKB
Cellular response to virus Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Immune response Source: UniProtKB
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: ARUK-UCL
Negative regulation of interleukin-17 production Source: BHF-UCL
Negative regulation of protein secretion Source: ARUK-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Negative regulation of vascular endothelial growth factor signaling pathway Source: ARUK-UCL
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of dendritic cell chemotaxis Source: UniProtKB
Positive regulation of interferon-gamma production Source: ComplexPortal
Positive regulation of lymphocyte proliferation Source: UniProtKB
Positive regulation of mononuclear cell proliferation Source: AgBase
Positive regulation of natural killer cell activation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: UniProtKB
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell activation Source: BHF-UCL
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of smooth muscle cell apoptotic process Source: BHF-UCL
Positive regulation of T cell mediated cytotoxicity Source: UniProtKB
Positive regulation of T cell proliferation Source: ComplexPortal
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
Response to UV-B Source: UniProtKB
Response to virus Source: UniProtKB

Secreted