Human Recombinant IL20 protein (V2LY-0526-LY4828)

Name: Human Recombinant IL20 protein
SKU: V2LY-0526-LY4828
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant IL20 protein consist of Amino Acid: 25-176 and predicts a molecular mass of 17.7 kDa.

Molecule Mass

17.7 kDa

Sequence

Amino Acid: 25-176

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

interleukin 20

Function

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

Biological Process

Positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Secreted

Dang, H., Hassan, Z., Jia, Z., Wu, Y., Xiao, H., Huang, W., ... & Wang, J. (2023). Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1. Fish & Shellfish Immunology, 132, 108445.

Kaymak, T., Kaya, B., Wuggenig, P., Nuciforo, S., Göldi, A., Oswald, F., ... & Swiss EoE Cohort Study Group. (2023). IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut, 72(5), 821-833.

Dayton, J. R., Yuan, Y., Pacumio, L. P., Dorflinger, B. G., Yoo, S. C., Olson, M. J., ... & Cruz-Orengo, L. (2021). Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Frontiers in cellular neuroscience, 15, 683687.

Lee, J. S., Hsu, Y. H., Chiu, Y. S., Jou, I., & Chang, M. S. (2020). Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats. Journal of Neuroinflammation, 17(1), 1-12.

Lu, S. W., Pan, H. C., Hsu, Y. H., Chang, K. C., Wu, L. W., Chen, W. Y., & Chang, M. S. (2020). IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature communications, 11(1), 4611.

Lin, T. Y., & Hsu, Y. H. (2020). IL-20 in acute kidney injury: role in pathogenesis and potential as a therapeutic target. International journal of molecular sciences, 21(3), 1009.

Moniruzzaman, M., Wang, R., Jeet, V., McGuckin, M. A., & Hasnain, S. Z. (2019). Interleukin (IL)-22 from IL-20 subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International journal of molecular sciences, 20(14), 3468.

Autieri, M. V. (2018). IL-19 and other IL-20 family member cytokines in vascular inflammatory diseases. Frontiers in Immunology, 9, 700.

Kragstrup, T. W., Andersen, T., Heftdal, L. D., Hvid, M., Gerwien, J., Sivakumar, P., ... & Deleuran, B. (2018). The IL-20 cytokine family in rheumatoid arthritis and spondyloarthritis. Frontiers in immunology, 9, 2226.

Chen, J., Caspi, R. R., & Chong, W. P. (2018). IL-20 receptor cytokines in autoimmune diseases. Journal of leukocyte biology, 104(5), 953-959.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL20 protein, Biotin Conjugated, (CAT#: V2LY-0526-LY4829)

Human Recombinant IL20 protein-1 (CAT#: V2LY-0526-LY4830)

Rat Recombinant IL20 protein (CAT#: V2LY-0526-LY9455)

Related Products

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Rat Recombinant IL20 protein (CAT#: V2LY-0526-LY9455)

Mouse Anti-IL20 Recombinant Antibody (CBYY-I0173) (CAT#: CBMAB-I0485-YY)

Rat Anti-IL20 Recombinant Antibody (CBYY-I0176) (CAT#: CBMAB-I0488-YY)

Mouse Anti-IL20 Recombinant Antibody (CBYY-I1385) (CAT#: CBMAB-I2555-YY)

Human Recombinant IL20 protein-1 (CAT#: V2LY-0526-LY4830)

Mouse Anti-IL20 Recombinant Antibody (CBYY-I1959) (CAT#: CBMAB-I3129-YY)

Mouse Anti-IL20 Recombinant Antibody (2H8) (CAT#: CBMAB-A4390-LY)

Mouse Anti-IL20 Recombinant Antibody (CBYY-I0174) (CAT#: CBMAB-I0486-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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