IL20
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq]
Full Name
interleukin 20
Function
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
Biological Process
Positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Secreted
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Anti-IL20 antibodies
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CompareTarget: IL20
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H8
Application*: WB, E
Target: IL20
Expressed Host: E. coli
Sequence: Amino Acid: 25-176
Target: IL20
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-176
Target: IL20
Expressed Host: E. coli
Sequence: Amino Acid: 25-176
Target: IL20
Expressed Host: E. coli
Sequence: Amino Acid: 25-176
Target: IL20
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1988
Application*: WB
Target: IL20
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1959
Application*: WB, IH
Target: IL20
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1385
Application*: WB
Target: IL20
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1344
Application*: E
Target: IL20
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I0910
Application*: WB
Target: IL20
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0176
Application*: E
Target: IL20
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0175
Application*: WB
Target: IL20
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0174
Application*: E
Target: IL20
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0173
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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