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Mouse Anti-IL20 Recombinant Antibody (2H8) (CBMAB-A4390-LY)

The product is antibody recognizes IL20. The antibody 2H8 immunoassay techniques such as: WB, ELISA.
See all IL20 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2H8
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
IL20 (NP_061194, 67 a.a. ~ 176 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interleukin 20
Introduction
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq]
Entrez Gene ID
50604
UniProt ID
Q9NYY1
Alternative Names
IL-20; IL10D; MGC96907; ZCYTO10
Function
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
Biological Process
Positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Secreted

Dang, H., Hassan, Z., Jia, Z., Wu, Y., Xiao, H., Huang, W., ... & Wang, J. (2023). Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1. Fish & Shellfish Immunology, 132, 108445.

Kaymak, T., Kaya, B., Wuggenig, P., Nuciforo, S., Göldi, A., Oswald, F., ... & Swiss EoE Cohort Study Group. (2023). IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut, 72(5), 821-833.

Dayton, J. R., Yuan, Y., Pacumio, L. P., Dorflinger, B. G., Yoo, S. C., Olson, M. J., ... & Cruz-Orengo, L. (2021). Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Frontiers in cellular neuroscience, 15, 683687.

Lee, J. S., Hsu, Y. H., Chiu, Y. S., Jou, I., & Chang, M. S. (2020). Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats. Journal of Neuroinflammation, 17(1), 1-12.

Lu, S. W., Pan, H. C., Hsu, Y. H., Chang, K. C., Wu, L. W., Chen, W. Y., & Chang, M. S. (2020). IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature communications, 11(1), 4611.

Lin, T. Y., & Hsu, Y. H. (2020). IL-20 in acute kidney injury: role in pathogenesis and potential as a therapeutic target. International journal of molecular sciences, 21(3), 1009.

Moniruzzaman, M., Wang, R., Jeet, V., McGuckin, M. A., & Hasnain, S. Z. (2019). Interleukin (IL)-22 from IL-20 subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International journal of molecular sciences, 20(14), 3468.

Autieri, M. V. (2018). IL-19 and other IL-20 family member cytokines in vascular inflammatory diseases. Frontiers in Immunology, 9, 700.

Kragstrup, T. W., Andersen, T., Heftdal, L. D., Hvid, M., Gerwien, J., Sivakumar, P., ... & Deleuran, B. (2018). The IL-20 cytokine family in rheumatoid arthritis and spondyloarthritis. Frontiers in immunology, 9, 2226.

Chen, J., Caspi, R. R., & Chong, W. P. (2018). IL-20 receptor cytokines in autoimmune diseases. Journal of leukocyte biology, 104(5), 953-959.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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