Rat Anti-IL20 Recombinant Antibody (CBYY-I0175) (CBMAB-I0487-YY)

Name: Rat Anti-IL20 Recombinant Antibody (CBYY-I0175)
SKU: CBMAB-I0487-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYY-I0175

Application

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

0.2 μm filtered solution in with Trehalose

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interleukin 20

Introduction

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Entrez Gene ID

58181

UniProt ID

Q9JKV9

Alternative Names

Interleukin 20

Function

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

Biological Process

Positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Secreted

Dang, H., Hassan, Z., Jia, Z., Wu, Y., Xiao, H., Huang, W., ... & Wang, J. (2023). Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1. Fish & Shellfish Immunology, 132, 108445.

Kaymak, T., Kaya, B., Wuggenig, P., Nuciforo, S., Göldi, A., Oswald, F., ... & Swiss EoE Cohort Study Group. (2023). IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut, 72(5), 821-833.

Dayton, J. R., Yuan, Y., Pacumio, L. P., Dorflinger, B. G., Yoo, S. C., Olson, M. J., ... & Cruz-Orengo, L. (2021). Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Frontiers in cellular neuroscience, 15, 683687.

Lee, J. S., Hsu, Y. H., Chiu, Y. S., Jou, I., & Chang, M. S. (2020). Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats. Journal of Neuroinflammation, 17(1), 1-12.

Lu, S. W., Pan, H. C., Hsu, Y. H., Chang, K. C., Wu, L. W., Chen, W. Y., & Chang, M. S. (2020). IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature communications, 11(1), 4611.

Lin, T. Y., & Hsu, Y. H. (2020). IL-20 in acute kidney injury: role in pathogenesis and potential as a therapeutic target. International journal of molecular sciences, 21(3), 1009.

Moniruzzaman, M., Wang, R., Jeet, V., McGuckin, M. A., & Hasnain, S. Z. (2019). Interleukin (IL)-22 from IL-20 subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International journal of molecular sciences, 20(14), 3468.

Autieri, M. V. (2018). IL-19 and other IL-20 family member cytokines in vascular inflammatory diseases. Frontiers in Immunology, 9, 700.

Kragstrup, T. W., Andersen, T., Heftdal, L. D., Hvid, M., Gerwien, J., Sivakumar, P., ... & Deleuran, B. (2018). The IL-20 cytokine family in rheumatoid arthritis and spondyloarthritis. Frontiers in immunology, 9, 2226.

Chen, J., Caspi, R. R., & Chong, W. P. (2018). IL-20 receptor cytokines in autoimmune diseases. Journal of leukocyte biology, 104(5), 953-959.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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