Human Recombinant IL2RA protein, ECD, His Tag-1 (V2LY-0526-LY2748)

Name: Human Recombinant IL2RA protein, ECD, His Tag-1
SKU: V2LY-0526-LY2748
Rating: 5 (1 reviews)

See all IL2RA antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IL2RA protein, ECD, His Tag consist of Amino Acid: 1-213 and predicts a molecular mass of 23.3 kDa.

Molecule Mass

23.3 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 1-213

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥97% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC. ≥90% as determined by SEC-MALS(Routinely tested).

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 2 Receptor Subunit Alpha

Alternative Names

CD25; Il2r; Ly-43

Function

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

Biological Process

Activation-induced cell death of T cellsIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of activated T cell proliferationIEA:Ensembl
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of T cell homeostatic proliferationIEA:Ensembl
Regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane

Involvement in disease

Diabetes mellitus, insulin-dependent, 10 (IDDM10):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41):
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.

Topology

Extracellular: 22-240
Helical: 241-259
Cytoplasmic: 260-272

Gil-Quiñones, S. R., Sepúlveda-Pachón, I. T., Sánchez Vanegas, G., & Gutierrez-Castañeda, L. D. (2021). Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis. PLoS One, 16(11), e0258499.

Joosse, M. E., Charbit-Henrion, F., Boisgard, R., Lindenbergh-Kortleve, D. J., Costes, L. M., Nugteren, S., ... & Samsom, J. N. (2021). Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis. Mucosal Immunology, 14(5), 1172-1182.

Borysewicz-Sańczyk, H., Sawicka, B., Wawrusiewicz-Kurylonek, N., Głowińska-Olszewska, B., Kadłubiska, A., Gościk, J., ... & Bossowski, A. (2020). Genetic association study of IL2RA, IFIH1, and CTLA-4 polymorphisms with autoimmune thyroid diseases and type 1 diabetes. Frontiers in pediatrics, 8, 481.

Nguyen, C. H., Schlerka, A., Grandits, A. M., Koller, E., van der Kouwe, E., Vassiliou, G. S., ... & Wieser, R. (2020). IL2RA promotes aggressiveness and stem cell–related properties of acute myeloid Leukemia. Cancer research, 80(20), 4527-4539.

Du, W., He, J., Zhou, W., Shu, S., Li, J., Liu, W., ... & Hu, D. (2019). High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia. Journal of translational medicine, 17, 1-14.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

de Oyarzabal, E., García-García, L., Rangel-Escareño, C., Ferreyra-Reyes, L., Orozco, L., Herrera, M. T., ... & Torres, M. (2019). Expression of USP18 and IL2RA is increased in individuals receiving latent tuberculosis treatment with isoniazid. Journal of Immunology Research, 2019.

Wang, X. X., & Chen, T. (2018). Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk. Immunological investigations, 47(5), 431-442.

Belot, M. P., Castell, A. L., Le Fur, S., & Bougnères, P. (2018). Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression. Epigenetics, 13(5), 459-472.

Xia, Z. L., Qin, Q. M., & Zhao, Q. Y. (2018). A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis. Neurological Research, 40(12), 1040-1047.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant IL2RA protein, ECD, His Tag-1?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL2RA protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1419)

Cynomolgus Recombinant IL2RA protein, hFc Tag (CAT#: V2LY-0526-LY1420)

Cynomolgus Recombinant IL2RA protein, His Tag (CAT#: V2LY-0526-LY1421)

Cynomolgus Recombinant IL2RA protein (CAT#: V2LY-0526-LY1422)

Human Recombinant IL2RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY2745)

Human Recombinant IL2RA protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2746)

Human Recombinant IL2RA protein, ECD, His Tag (CAT#: V2LY-0526-LY2747)

Human Recombinant IL2RA protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2749)

Mouse Recombinant IL2RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY7979)

Mouse Recombinant IL2RA protein, ECD, His Tag (CAT#: V2LY-0526-LY7980)

Related Products

Mouse Anti-IL2RA Recombinant Antibody (143-13) (CAT#: CBMAB-C0328-LY)

Mouse Anti-IL2RA Recombinant Antibody (CBYY-I0640) (CAT#: CBMAB-I1427-YY)

Mouse Anti-IL2RA Recombinant Antibody (CB266) (CAT#: CBMAB-CS266LY)

Rat Anti-IL2RA Recombinant Antibody (7D4) (CAT#: CBMAB-C8626-LY)

Cynomolgus Recombinant IL2RA protein, hFc Tag (CAT#: V2LY-0526-LY1420)

Mouse Anti-IL2RA Recombinant Antibody (CBWJC-3826) (CAT#: CBMAB-C5097WJ)

Rat Anti-IL2RA Recombinant Antibody (280406) (CAT#: CBMAB-C0781-LY)

Mouse Anti-IL2RA Recombinant Antibody (5J69) (CAT#: CBMAB-C7755-LY)

Mouse Anti-IL2RA Recombinant Antibody (CBYY-I1532) (CAT#: CBMAB-I2702-YY)

Rat Recombinant IL2RA protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY9221)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry