IL2RA
Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha).
Full Name
Interleukin 2 Receptor Subunit Alpha
Alternative Names
CD25; Il2r; Ly-43
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Biological Process
Activation-induced cell death of T cellsIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of activated T cell proliferationIEA:Ensembl
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of T cell homeostatic proliferationIEA:Ensembl
Regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of activated T cell proliferationIEA:Ensembl
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of T cell homeostatic proliferationIEA:Ensembl
Regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Involvement in disease
Diabetes mellitus, insulin-dependent, 10 (IDDM10):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41):
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41):
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
Topology
Extracellular: 22-240
Helical: 241-259
Cytoplasmic: 260-272
Helical: 241-259
Cytoplasmic: 260-272
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Anti-IL2RA antibodies
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CompareTarget: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A546
Application*: ELISA, IHC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rabbit
Clone: KEI-alpha1
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0584
Application*: F, IF, P, C
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EC176
Application*: P
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: AG107
Application*: B, F, C, IP, WB
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AG106
Application*: E, F, IF, IP, WB
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: A545
Application*: FC, IHC, IP
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1161
Application*: E, F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1159
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: AP-MAB0710
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: PC61.5.3
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: PC61.5
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: OX39
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: NLDC-145
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: P4A10
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: PC61
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 13H99
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep
Clone: 9.14
Application*: C, P, F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 7G19
Application*: C, F
Target: IL2RA
Host: Rat
Antibody Isotype: IgM
Specificity: Mouse
Clone: 7D4
Application*: P, F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 745520
Application*: F, MC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 6A263
Application*: E, F, IH
Target: IL2RA
Host: Rat
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: 5K251
Application*: F, IP
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 14L178
Application*: F, IH, IP
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 3C7
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 280414
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 280406
Application*: F, MC
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 280401
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT292
Application*: P, IF
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: CBT2422
Application*: WB, IH, IC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A544
Application*: IF, IP
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7F3
Application*: IHC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB479A
Application*: ELISA, IHC
Target: IL2RA
Host: Goat
Antibody Isotype: IgG
Specificity: Human
Clone: HI25a
Application*: ELISA, FC, IHC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB266
Application*: IF, FC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB265
Application*: IF, FC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB264
Application*: IF, FC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB263
Application*: IF, FC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB262
Application*: IF, FC
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6K5F
Application*: WB
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D6
Application*: WB, E
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Q22
Application*: IH
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: YTH906.9HL
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: MEM-140
Application*: F
Target: IL2RA
Host: Mouse
Specificity: Human
Clone: CBCNC-617
Application*: IH
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBCNC-616
Application*: FC, WB
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NR-72
Application*: FN, FC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5G44
Application*: E, IH
Target: IL2RA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 14D27
Application*: FC
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP176
Application*: P
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rabbit
Clone: CBWJC-3826
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBWJC-3825
Application*: F, C, IP
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-3824
Application*: F, IF
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3823
Application*: E, F, IF
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-3822
Application*: P, WB
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-3821
Application*: P, IC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3820
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3818
Application*: E, F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3817
Application*: EC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBWJC-3815
Application*: E, F, WB
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M-A251
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HI25a
Application*: E, F, IH
Target: IL2RA
Host: Rat
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: CBWJC-2195
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBWJC-2194
Application*: F, FN
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2193
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-2192
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-2191
Application*: F, IH, P, MC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0030
Application*: WB, P, SE
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2195
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-2483
Application*: WB, E, IH, IF
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1808
Application*: F, IH, FN
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1831
Application*: F, IH
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1836
Application*: EC
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2654
Application*: P
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: IL2RA/423
Application*: FN, F, IF
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0659
Application*: E, C, P, N, WB
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1036
Application*: WB, IH, IC, EC
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1460
Application*: F, IH
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXC-1425
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1576
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1677
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBXC-1567
Application*: F, IH
Target: IL2RA
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0881
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-2233
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1037
Application*: F
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Daclizumab
Application*: F, N, MC
Target: IL2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: Basiliximab
Application*: WB, F, IH, N, IF, MC
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2415
Application*: F, IF
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2570
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C2569
Application*: E, F, IH
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep
Clone: CBYY-C2568
Application*: F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2567
Application*: E, F, N
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0608
Application*: F, IH
Target: IL2RA
Host: Rat
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: CBYY-C0451
Application*: F, IP
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0387
Application*: F, IF, IH
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0258
Application*: IF, F
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0209
Application*: F
Target: IL2RA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0099
Application*: F, IH, IP
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0098
Application*: F, IP, WB
Target: IL2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0080
Application*: F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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