Human Recombinant LIF protein, hFc Tag (V2LY-0526-LY5293)

Name: Human Recombinant LIF protein, hFc Tag
SKU: V2LY-0526-LY5293
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant LIF protein, hFc Tag consist of Amino Acid: 1-202 and predicts a molecular mass of 46.7 kDa.

Molecule Mass

46.7 kDa

Sequence

Amino Acid: 1-202

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, TCEP, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Leukemia Inhibitory Factor

Function

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Biological Process

Blood vessel remodelingIEA:Ensembl
DecidualizationIEA:Ensembl
Embryo implantationIEA:Ensembl
Immune responseIEA:InterPro
Leukemia inhibitory factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Lung alveolus developmentIEA:Ensembl
Lung lobe morphogenesisIEA:Ensembl
Lung vasculature developmentIEA:Ensembl
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Muscle organ morphogenesisIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Negative regulation of meiotic nuclear divisionIEA:Ensembl
Neuron developmentIEA:Ensembl
Positive regulation of astrocyte differentiationIEA:Ensembl
Positive regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of histone H3-K27 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of metanephric nephron tubule epithelial cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIEA:Ensembl
Spongiotrophoblast differentiationIEA:Ensembl
Stem cell differentiationIEA:Ensembl
Stem cell population maintenanceIEA:Ensembl
Trophoblast giant cell differentiationIEA:Ensembl
Tyrosine phosphorylation of STAT proteinIEA:Ensembl

Cellular Location

Secreted

Feng, Y., Ye, D., Wang, Z., Pan, H., Lu, X., Wang, M., ... & Wan, J. (2022). The role of interleukin-6 family members in cardiovascular diseases. Frontiers in cardiovascular medicine, 9, 818890.

Abaurrea, A., Araujo, A. M., & Caffarel, M. M. (2021). The role of the il-6 cytokine family in epithelial–mesenchymal plasticity in cancer progression. International journal of molecular sciences, 22(15), 8334.

van Duijneveldt, G., Griffin, M. D., & Putoczki, T. L. (2020). Emerging roles for the IL-6 family of cytokines in pancreatic cancer. Clinical Science, 134(16), 2091-2115.

Kang, S., Narazaki, M., Metwally, H., & Kishimoto, T. (2020). Historical overview of the interleukin-6 family cytokine. Journal of Experimental Medicine, 217(5).

Murakami, M., Kamimura, D., & Hirano, T. (2019). Pleiotropy and specificity: insights from the interleukin 6 family of cytokines. Immunity, 50(4), 812-831.

Lokau, J., Schoeder, V., Haybaeck, J., & Garbers, C. (2019). Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma. Cancers, 11(11), 1704.

Rasmussen, J. M., Graham, A. M., Entringer, S., Gilmore, J. H., Styner, M., Fair, D. A., ... & Buss, C. (2019). Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life. Neuroimage, 185, 825-835.

Jones, S. A., & Jenkins, B. J. (2018). Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature reviews immunology, 18(12), 773-789.

Rose-John, S. (2018). Interleukin-6 family cytokines. Cold Spring Harbor perspectives in biology, 10(2), a028415.

Unver, N., & McAllister, F. (2018). IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine & growth factor reviews, 41, 10-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Influenzavirus A Recombinant H1N1 (A/California/04/2009) Hemagglutinin-specific B cell probe protein, His Tag (CAT#: V2LY-0526-LY365)

Influenzavirus A Recombinant H1N1 (A/California/04/2009) Hemagglutinin-specific B cell probe (Y108F) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY366)

Influenzavirus A Recombinant H1N1 (A/California/04/2009) Hemagglutinin-specific B cell probe (Y108F) protein, Biotin Conjugated, His & AVI Tag-1 (CAT#: V2LY-0526-LY367)

Cynomolgus, Rhesus Recombinant LIF protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1725)

Human Recombinant LIF protein, His Tag (CAT#: V2LY-0526-LY5294)

Human Recombinant LIF protein (CAT#: V2LY-0526-LY5295)

Mouse Recombinant LIF protein, His Tag (CAT#: V2LY-0526-LY8616)

Mouse Recombinant LIF protein (CAT#: V2LY-0526-LY8617)

Mouse Recombinant LIFR protein, His Tag (CAT#: V2LY-0526-LY8618)

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Mouse Recombinant LIF protein, His Tag (CAT#: V2LY-0526-LY8616)

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Influenzavirus A Recombinant H1N1 (A/California/04/2009) Hemagglutinin-specific B cell probe protein, His Tag (CAT#: V2LY-0526-LY365)

Human Recombinant LIF protein (CAT#: V2LY-0526-LY5295)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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