Human Recombinant LILRB1 protein, ECD, His Tag (V2LY-0526-LY4979)

LILRB1

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952).
Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885).
Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647).
Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799).
Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251).

Adaptive immune responseIEA:UniProtKB-KW
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Dendritic cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune response-inhibiting cell surface receptor signaling pathway1 PublicationNAS:BHF-UCL
Negative regulation of alpha-beta T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of CD8-positive, alpha-beta T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of dendritic cell apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of dendritic cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interferon-beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mononuclear cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast developmentManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of serotonin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of T cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transforming growth factor beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gamma-delta T cell activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of macrophage cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase II1 PublicationNAS:BHF-UCL
Receptor internalizationManual Assertion Based On ExperimentTAS:UniProtKB
Response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
T cell proliferation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB

Cell membrane
Isoform 5:
Secreted

Extracellular: 24-461
Helical: 462-482
Cytoplasmic: 483-650

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.