LILRB1

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

LILRB1

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952).
Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885).
Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647).
Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799).
Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251).

Adaptive immune responseIEA:UniProtKB-KW
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Dendritic cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune response-inhibiting cell surface receptor signaling pathway1 PublicationNAS:BHF-UCL
Negative regulation of alpha-beta T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of CD8-positive, alpha-beta T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of dendritic cell apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of dendritic cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interferon-beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mononuclear cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast developmentManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of serotonin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of T cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transforming growth factor beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gamma-delta T cell activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of macrophage cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase II1 PublicationNAS:BHF-UCL
Receptor internalizationManual Assertion Based On ExperimentTAS:UniProtKB
Response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
T cell proliferation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB

Cell membrane
Isoform 5:
Secreted

Extracellular: 24-461
Helical: 462-482
Cytoplasmic: 483-650

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.