Human Recombinant LRIG1 protein, hFc Tag (V2LY-0526-LY5343)

Name: Human Recombinant LRIG1 protein, hFc Tag
SKU: V2LY-0526-LY5343
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant LRIG1 protein, hFc Tag consist of Amino Acid: 1-779 and predicts a molecular mass of 108 kDa.

Molecule Mass

108 kDa

Verified

HPLC

Sequence

Amino Acid: 1-779

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

leucine rich repeats and immunoglobulin like domains 1

Function

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

Biological Process

Hair cycle processIEA:Ensembl
InnervationIEA:Ensembl
Otolith morphogenesisIEA:Ensembl
Sensory perception of soundIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 35-794
Helical: 795-815
Cytoplasmic: 816-1093

Moon, J. S., Ho, C. C., Park, J. H., Park, K., Shin, B. Y., Lee, S. H., ... & Lee, S. K. (2023). Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis. Nature Communications, 14(1), 5382.

Hopton, R. E., Jahahn, N. J., & Zemper, A. E. (2023). Lrig1 drives cryptogenesis and restrains proliferation during colon development. American Journal of Physiology-Gastrointestinal and Liver Physiology, 325(6), G570-G581.

Ji, Y., Kumar, R., Gokhale, A., Chao, H. P., Rycaj, K., Chen, X., ... & Tang, D. G. (2022, July). LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor. In Seminars in cancer biology (Vol. 82, pp. 120-133). Academic Press.

Umeh-Garcia, M., O’Geen, H., Simion, C., Gephart, M. H., Segal, D. J., & Sweeney, C. A. (2022). Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer. British journal of cancer, 127(3), 436-448.

Billing, O., Holmgren, Y., Nosek, D., Hedman, H., & Hemmingsson, O. (2021). LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance. Oncogene, 40(21), 3707-3718.

Marqués-Torrejón, M. Á., Williams, C. A., Southgate, B., Alfazema, N., Clements, M. P., Garcia-Diaz, C., ... & Pollard, S. M. (2021). LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells. Nature communications, 12(1), 2594.

Bakherad, M., Salimi, M., Angaji, S. A., Mahjoubi, F., & Majidizadeh, T. (2021). LRIG1 expression and colorectal cancer prognosis. BMC Medical Genomics, 14, 1-6.

Gao, Y., Liu, C., Zhao, X., Liu, C., Bi, W., & Jia, J. (2021). hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma. Annals of Translational Medicine, 9(15).

Li, W., & Zhou, Y. (2019). LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial–mesenchymal transition. Bioscience Reports, 39(1), BSR20181165.

Li, Q., Liu, B., Chao, H. P., Ji, Y., Lu, Y., Mehmood, R., ... & Tang, D. G. (2019). LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer. Nature communications, 10(1), 5494.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant LRIG1 protein, His Tag (CAT#: V2LY-0526-LY8626)

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Mouse Recombinant LRIG1 protein, His Tag (CAT#: V2LY-0526-LY8626)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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