Human Recombinant Mak, Active protein, GST Tag (V2LY-0526-LY5420)

Name: Human Recombinant Mak, Active protein, GST Tag
SKU: V2LY-0526-LY5420
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant Mak, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 78 kDa.

Molecule Mass

78 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

male germ cell-associated kinase

Function

Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity).
Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cilium assemblyManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Intraciliary transportManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of non-motile cilium assemblyIEA:Ensembl
Photoreceptor cell maintenanceISS:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Spermatogenesis1 PublicationNAS:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Midbody
Cell projection, cilium, photoreceptor outer segment
Photoreceptor inner segment
Localized in both the connecting cilia and the outer segment axonemes (By similarity).
Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.

Involvement in disease

Retinitis pigmentosa 62 (RP62):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

PTM

Autophosphorylated. Phosphorylated on serine and threonine residues.

Matsushime, H., Jinno, A., Takagi, N., & Shibuya, M. (2023). A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Molecular and Cellular Biology.

Gibson‐Corley, K. N., Cranston, C., Anfinson, K., Kaalberg, E., Han, I., Slusarski, D. C., ... & Tucker, B. A. (2019). Development of gene augmentation strategy for the treatment of MAK associated Retinitis Pigmentosa. The FASEB Journal, 33(S1), 802-20.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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