Human Recombinant MLK3, Active protein, GST Tag (V2LY-0526-LY5604)

Name: Human Recombinant MLK3, Active protein, GST Tag
SKU: V2LY-0526-LY5604
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant MLK3, Active protein, GST Tag consist of Amino Acid: 1-488 and predicts a molecular mass of 83 kDa.

Molecule Mass

83 kDa

Sequence

Amino Acid: 1-488

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

mitogen-activated protein kinase kinase kinase 11

Function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Biological Process

Cell cycle G1/S phase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Cell deathIEA:Ensembl
JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron apoptotic processIEA:Ensembl
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Location is cell cycle dependent.

PTM

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.

Liu, P. F., Chen, C. F., Ger, L. P., Tsai, W. L., Tseng, H. H., Lee, C. H., ... & Shu, C. W. (2022). MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. Journal of Cellular Physiology, 237(11), 4275-4291.

Qi, A., Ru, W., Yang, H., Yang, Y., Tang, J., Yang, S., ... & Chen, H. (2022). Circular RNA ACTA1 acts as a sponge for miR-199a-5p and miR-433 to regulate bovine myoblast development through the MAP3K11/MAP2K7/JNK pathway. Journal of Agricultural and Food Chemistry, 70(10), 3357-3373.

He, S., Huang, Y., Dong, S., Qiao, C., Yang, G., Zhang, S., ... & Yan, M. (2020). MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium. Journal of Translational Medicine, 18, 1-19.

Li, Y., Wang, D., Li, X., Shao, Y., He, Y., Yu, H., & Ma, Z. (2019). MiR-199a-5p suppresses non-small cell lung cancer via targeting MAP3K11. Journal of Cancer, 10(11), 2472.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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