MAP3K11

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq]

Full Name

mitogen-activated protein kinase kinase kinase 11

Function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Biological Process

Cell cycle G1/S phase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Cell deathIEA:Ensembl
JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron apoptotic processIEA:Ensembl
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Location is cell cycle dependent.

PTM

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.