Human Recombinant NLGN4X protein, His Tag (V2LY-0526-LY5807)

Name: Human Recombinant NLGN4X protein, His Tag
SKU: V2LY-0526-LY5807
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant NLGN4X protein, His Tag consist of Amino Acid: 1-676 and predicts a molecular mass of 72.9 kDa.

Molecule Mass

72.9 kDa

Sequence

Amino Acid: 1-676

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Neuroligin 4, X-Linked

Function

Putative neuronal cell surface protein involved in cell-cell-interactions.

Biological Process

Adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Brainstem developmentBy SimilarityISS:BHF-UCL
Cell-cell junction organization1 PublicationNAS:UniProtKB
Cerebellum developmentBy SimilarityISS:BHF-UCL
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
LearningManual Assertion Based On ExperimentIMP:BHF-UCL
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of excitatory postsynaptic potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Neuron cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiation1 PublicationNAS:BHF-UCL
Organ growthBy SimilarityISS:BHF-UCL
Postsynaptic membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Presynapse assemblyManual Assertion Based On ExperimentTAS:ARUK-UCL
Presynaptic membrane assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Social behaviorManual Assertion Based On ExperimentIMP:UniProtKB
Synapse organizationManual Assertion Based On ExperimentIMP:UniProtKB
Synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane
Cell junction, synapse, postsynaptic density membrane

Involvement in disease

Autism, X-linked 2 (AUTSX2):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Asperger syndrome, X-linked, 2 (ASPGX2):
A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.

Topology

Extracellular: 42-676
Helical: 677-697
Cytoplasmic: 698-816

Krämer, C., Kilian, M., Chih, Y. C., Kourtesakis, A., Hoffmann, D. C., Boschert, T., ... & Bunse, L. (2024). NLGN4X TCR transgenic T cells to treat gliomas. Neuro-oncology, 26(2), 266-278.

Chung, J., Sun, X., Schmidt, M. A., Song, Y. E., Grunin, M., Palmer, E. L., ... & Martin, E. R. (2023). Variants near X‐Chromosome Genes NLGN4X and PTCHD1 are Significantly Associated with Alzheimer’s Disease Risk. Alzheimer's & Dementia, 19, e067117.

Kopp, N., Amarillo, I., Martinez‐Agosto, J., & Quintero‐Rivera, F. (2021). Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder: Clinical, cytogenetic, and molecular characterization. American Journal of Medical Genetics Part A, 185(3), 894-900.

Nguyen, T. A., Wu, K., Pandey, S., Lehr, A. W., Li, Y., Bemben, M. A., ... & Roche, K. W. (2020). A cluster of autism-associated variants on X-linked NLGN4X functionally resemble NLGN4Y. Neuron, 106(5), 759-768.

Sun, H., Yang, Y., Zhang, L., Wu, H., Zhang, H., & Li, H. (2019). Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis. Annals of General Psychiatry, 18(1), 1-6.

Maxeiner, S., Sester, M., & Krasteva-Christ, G. (2019). Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y. Biology of sex Differences, 10(1), 1-8.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NLGN4X protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5806)

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Human Recombinant NLGN4X protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5806)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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