Mouse Anti-NLGN4X Recombinant Antibody (A1374) (CBMAB-AP12571LY)

The product is antibody recognizes NLGN4. The antibody A1374 immunoassay techniques such as: ICC/IF, IHC, WB.
See all NLGN4X antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse

Clone

A1374

Antibody Isotype

IgG1

Application

ICC/IF, IHC, WB

Basic Information

Immunogen

Fusion protein amino acids 782-945 (intracellular C-terminus) of mouse Neuroligin 4.

Specificity

Mouse

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Neuroligin 4, X-Linked

Entrez Gene ID

100113365

UniProt ID

B0F2B4

Alternative Names

ASPGX2 Antibody, AUTSX2 Antibody, HLNX Antibody, HNLX Antibody, KIAA1260 Antibody, MGC22376 Antibody, NLGN Antibody, NLGN4 Antibody, NLGN4X Antibody, neuroligin-4 X-linked Antibody, neuroligin X Antibody, neuroligin 4 Antibody, X-linked Antibody

Function

Putative neuronal cell surface protein involved in cell-cell-interactions.

Biological Process

Adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Brainstem developmentBy SimilarityISS:BHF-UCL
Cell-cell junction organization1 PublicationNAS:UniProtKB
Cerebellum developmentBy SimilarityISS:BHF-UCL
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
LearningManual Assertion Based On ExperimentIMP:BHF-UCL
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of excitatory postsynaptic potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Neuron cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiation1 PublicationNAS:BHF-UCL
Organ growthBy SimilarityISS:BHF-UCL
Postsynaptic membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Presynapse assemblyManual Assertion Based On ExperimentTAS:ARUK-UCL
Presynaptic membrane assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Social behaviorManual Assertion Based On ExperimentIMP:UniProtKB
Synapse organizationManual Assertion Based On ExperimentIMP:UniProtKB
Synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane
Cell junction, synapse, postsynaptic density membrane

Involvement in disease

Autism, X-linked 2 (AUTSX2):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Asperger syndrome, X-linked, 2 (ASPGX2):
A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.

Topology

Extracellular: 42-676
Helical: 677-697
Cytoplasmic: 698-816

References

Krämer, C., Kilian, M., Chih, Y. C., Kourtesakis, A., Hoffmann, D. C., Boschert, T., ... & Bunse, L. (2024). NLGN4X TCR transgenic T cells to treat gliomas. Neuro-oncology, 26(2), 266-278.

Chung, J., Sun, X., Schmidt, M. A., Song, Y. E., Grunin, M., Palmer, E. L., ... & Martin, E. R. (2023). Variants near X‐Chromosome Genes NLGN4X and PTCHD1 are Significantly Associated with Alzheimer’s Disease Risk. Alzheimer's & Dementia, 19, e067117.

Kopp, N., Amarillo, I., Martinez‐Agosto, J., & Quintero‐Rivera, F. (2021). Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder: Clinical, cytogenetic, and molecular characterization. American Journal of Medical Genetics Part A, 185(3), 894-900.

Nguyen, T. A., Wu, K., Pandey, S., Lehr, A. W., Li, Y., Bemben, M. A., ... & Roche, K. W. (2020). A cluster of autism-associated variants on X-linked NLGN4X functionally resemble NLGN4Y. Neuron, 106(5), 759-768.

Sun, H., Yang, Y., Zhang, L., Wu, H., Zhang, H., & Li, H. (2019). Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis. Annals of General Psychiatry, 18(1), 1-6.

Maxeiner, S., Sester, M., & Krasteva-Christ, G. (2019). Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y. Biology of sex Differences, 10(1), 1-8.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-NLGN4X Recombinant Antibody (S98-7)

Mouse Anti-NLGN4X Recombinant Antibody (5A11)

Mouse Anti-NLGN4X Recombinant Antibody (CBWJN-1431)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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