Human Recombinant PDGFC protein, hFc Tag (V2LY-0526-LY6065)

Name: Human Recombinant PDGFC protein, hFc Tag
SKU: V2LY-0526-LY6065
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant PDGFC protein, hFc Tag consist of Amino Acid: 235-345 and predicts a molecular mass of 39 kDa.

Molecule Mass

39 kDa

Sequence

Amino Acid: 235-345

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glycerol, Urea

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Platelet Derived Growth Factor C

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Biological Process

Activation of transmembrane receptor protein tyrosine kinase activityIEA:Ensembl
Animal organ morphogenesisIEA:Ensembl
Bone developmentIEA:Ensembl
Cellular response to amino acid stimulusIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:UniProtKB
Digestive tract developmentIEA:Ensembl
Embryonic organ developmentIEA:InterPro
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl

Cellular Location

Cytoplasm, cytosol
Secreted
Nucleus
Cytoplasmic granule
Cell membrane
Sumoylated form is predominant in the nucleus (PubMed:15247255).
Stored in alpha granules in platelets (PubMed:15061151).

PTM

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
Sumoylated with SUMO1.
N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant PDGFC protein, hFc Tag (CAT#: V2LY-0526-LY1624)

Human Recombinant PDGFC protein, His Tag (CAT#: V2LY-0526-LY6066)

Mouse Recombinant PDGFC protein, hFc Tag (CAT#: V2LY-0526-LY8753)

Mouse Recombinant PDGFC protein, His Tag (CAT#: V2LY-0526-LY8754)

Related Products

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Mouse Anti-PDGFC Recombinant Antibody (14L796) (CAT#: CBMAB-P1249-YC)

Human Recombinant PDGFC protein, His Tag (CAT#: V2LY-0526-LY6066)

Cynomolgus Recombinant PDGFC protein, hFc Tag (CAT#: V2LY-0526-LY1624)

Mouse Recombinant PDGFC protein, His Tag (CAT#: V2LY-0526-LY8754)

Mouse Recombinant PDGFC protein, hFc Tag (CAT#: V2LY-0526-LY8753)

Mouse Anti-PDGFC Recombinant Antibody (5F12) (CAT#: CBMAB-P1251-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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