Human Recombinant PFKM protein, GST Tag (V2LY-0526-LY6128)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant PFKM protein, GST Tag consist of Amino Acid: 2-780 and predicts a molecular mass of 112.9 kDa.
Molecule Mass
112.9 kDa
Sequence
Amino Acid: 2-780
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Glycerol, Teween
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
phosphofructokinase, muscle
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Biological Process
Canonical glycolysisManual Assertion Based On ExperimentIBA:GO_Central
Fructose 1,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose 6-phosphate metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Glucose homeostasisIEA:Ensembl
Glycogen catabolic processIEA:Ensembl
Glycolysis from storage polysaccharide through glucose-1-phosphateIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Glycolytic process through fructose-6-phosphateManual Assertion Based On ExperimentIMP:CAFA
Muscle cell cellular homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of insulin secretionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cytoplasm
Involvement in disease
Glycogen storage disease 7 (GSD7):
A metabolic disorder characterized by exercise intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise.
PTM
GlcNAcylation decreases enzyme activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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