Human Recombinant RAMP3 protein, hFc Tag (V2LY-0526-LY6455)

Name: Human Recombinant RAMP3 protein, hFc Tag
SKU: V2LY-0526-LY6455
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant RAMP3 protein, hFc Tag consist of Amino Acid: 1-118 and predicts a molecular mass of 37.8 kDa.

Molecule Mass

37.8 kDa

Sequence

Amino Acid: 1-118

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

receptor (G protein-coupled) activity modifying protein 3

Function

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process adrenomedullin receptor signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process amylin receptor signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to estradiol stimulusISS:UniProtKB
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cross-receptor inhibition within G protein-coupled receptor heterodimerManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathway involved in heart processISS:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process positive regulation of calcium ion import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of protein kinase A signalingManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process receptor internalizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to amyloid-betaManual Assertion Based On ExperimentIGI:ARUK-UCL

Cellular Location

Cell membrane
Membrane
Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Topology

Extracellular: 24-118
Helical: 119-138
Cytoplasmic: 139-148

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RAMP3 Recombinant Antibody (1C11) (CAT#: CBMAB-R1262-CN)

Mouse Anti-RAMP3 Recombinant Antibody (CBCNR-172) (CAT#: CBMAB-R1263-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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