Human Recombinant RANBP2 , Active protein, His Tag (V2LY-0526-LY6457)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481).
Binds single-stranded RNA (in vitro) (PubMed:7775481).
May bind DNA (PubMed:7775481).
Component of the nuclear export pathway (PubMed:10078529).
Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529).
Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184).
Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726).
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830).
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process NLS-bearing protein import into nucleusManual Assertion Based On ExperimentIMP:GO_Central
Biological Process nuclear export1 PublicationIC:ComplexPortal
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process positive regulation of glucokinase activityIEA:Ensembl
Biological Process protein foldingIEA:InterPro
Biological Process protein peptidyl-prolyl isomerizationIEA:InterPro
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of gluconeogenesisIEA:Ensembl
Nucleus membrane
Nucleus, nuclear pore complex
Nucleus envelope
Detected in diffuse and discrete intranuclear foci (PubMed:11839768).
Cytoplasmic filaments (PubMed:7775481).
A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem.
The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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