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Mouse Anti-RANBP2 Recombinant Antibody (CBCNR-910) (CBMAB-R0092-CN)

This product is a Mouse antibody that recognizes RANBP2. The antibody CBCNR-910 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all RANBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-910
Antibody Isotype
IgG1
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.3 mg/mL

Target

Full Name
RAN Binding Protein 2
Introduction
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5903
UniProt ID
P49792
Alternative Names
RAN Binding Protein 2; Acute Necrotizing Encephalopathy 1 (Autosomal Dominant); Nuclear Pore Complex Protein Nup358; Ran-Binding Protein 2; 358 KDa Nucleoporin; Nucleoporin Nup358; Nucleoporin 358; NUP358; P270; Transformation-Related Protein 2;
Function
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224).
Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481).
Binds single-stranded RNA (in vitro) (PubMed:7775481).
May bind DNA (PubMed:7775481).
Component of the nuclear export pathway (PubMed:10078529).
Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529).
Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184).
Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726).
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830).
Biological Process
Biological Process centrosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process NLS-bearing protein import into nucleusManual Assertion Based On ExperimentIMP:GO_Central
Biological Process nuclear export1 PublicationIC:ComplexPortal
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process positive regulation of glucokinase activityIEA:Ensembl
Biological Process protein foldingIEA:InterPro
Biological Process protein peptidyl-prolyl isomerizationIEA:InterPro
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of gluconeogenesisIEA:Ensembl
Cellular Location
Nucleus
Nucleus membrane
Nucleus, nuclear pore complex
Nucleus envelope
Detected in diffuse and discrete intranuclear foci (PubMed:11839768).
Cytoplasmic filaments (PubMed:7775481).
Involvement in disease
Encephalopathy, acute, infection-induced, 3 (IIAE3):
A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem.
PTM
Polyubiquitinated by PRKN, which leads to proteasomal degradation.
The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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