Human Recombinant RELT protein, His & hFc Tag (V2LY-0526-LY6489)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
His & hFc Tag
Protein Construction
This product is Human Recombinant RELT protein, His & hFc Tag consist of Amino Acid: 1-160 and predicts a molecular mass of 42 kDa.
Molecule Mass
42 kDa
Sequence
Amino Acid: 1-160
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
RELT, TNF Receptor
Function
May play a role in apoptosis (PubMed:28688764, PubMed:19969290).
Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727).
Involved in dental enamel formation (PubMed:30506946).
Biological Process
Biological Process amelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Cytoplasm, perinuclear region
Involvement in disease
Amelogenesis imperfecta 3C (AI3C):
An autosomal recessive form of amelogenesis imperfecta, a defect of enamel formation. AI3C is characterized by generalized enamel hypocalcification affecting primary and secondary dentition. The surface of the enamel is rough and often stained. After eruption, the occlusal enamel on the molars disappears due to attrition, leaving a ring of intact enamel remaining on the sides.
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-430
PTM
Phosphorylated in vitro by OXSR1 (PubMed:16389068).
Phosphorylated by STK39 (PubMed:16530727).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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