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RELT

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Full Name
RELT, TNF Receptor
Function
May play a role in apoptosis (PubMed:28688764, PubMed:19969290).
Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727).
Involved in dental enamel formation (PubMed:30506946).
Biological Process
Biological Process amelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Cytoplasm, perinuclear region
Involvement in disease
Amelogenesis imperfecta 3C (AI3C):
An autosomal recessive form of amelogenesis imperfecta, a defect of enamel formation. AI3C is characterized by generalized enamel hypocalcification affecting primary and secondary dentition. The surface of the enamel is rough and often stained. After eruption, the occlusal enamel on the molars disappears due to attrition, leaving a ring of intact enamel remaining on the sides.
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-430
PTM
Phosphorylated in vitro by OXSR1 (PubMed:16389068).
Phosphorylated by STK39 (PubMed:16530727).
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Anti-RELT antibodies

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Mouse Anti-RELT Recombinant Antibody (3F8) (CBMAB-A9303-LY)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: WB, E
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (CBYJT-1628) (CBMAB-T0674-YJ)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-1628
Application*: F
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (CBYJT-1627) (CBMAB-T0673-YJ)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1627
Application*: E, WB
Datasheet SDS

Rabbit Anti-RELT Recombinant Antibody (CBYJT-1626) (CBMAB-T0672-YJ)

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Target: RELT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1626
Application*: E
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (CBYJT-1625) (CBMAB-T0671-YJ)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1625
Application*: IF, IC
Datasheet SDS

RELT Matched Antibody Pair (985) (APMAB-985LY)

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Target: RELT
Specificity: Human
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (CBCNR-396) (CBMAB-R2134-CN)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-396
Application*: E, WB
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (8G28) (CBMAB-R2133-CN)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 8G28
Application*: F
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (3F8) (CBMAB-R2132-CN)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: E, WB
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (14L820) (CBMAB-R2131-CN)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L820
Application*: F
Datasheet SDS

Rabbit Anti-RELT Recombinant Antibody (135) (CBMAB-R2130-CN)

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Target: RELT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 135
Application*: E
Datasheet SDS

Rabbit Anti-RELT Recombinant Antibody (111) (CBMAB-R2129-CN)

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Target: RELT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 111
Application*: E
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (01) (CBMAB-R2128-CN)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 01
Application*: IF, IF
Datasheet SDS

Mouse Anti-RELT Recombinant Antibody (238104) (CBMAB-R0209-CN)

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Target: RELT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 238104
Application*: F, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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