Mouse Anti-RELT Recombinant Antibody (CBYJT-1625) (CBMAB-T0671-YJ)

Name: Mouse Anti-RELT Recombinant Antibody (CBYJT-1625)
SKU: CBMAB-T0671-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1625

Application

IF, ICC

Immunogen

Recombinant Human RELT/TNFRSF19L protein. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RELT/TNFRSF19L

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

RELT, TNF Receptor

Introduction

RELT is a member of the TNF-receptor superfamily. It is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). It is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response.

Entrez Gene ID

84957

UniProt ID

Q969Z4

Alternative Names

RELT, TNF Receptor; Receptor Expressed In Lymphoid Tissues; RELT Tumor Necrosis Factor Receptor; TNFRSF19L; Tumor Necrosis Factor Receptor Superfamily, Member 19-Like; Tumor Necrosis Factor Receptor Superfamily Member 19L; TRLT

Function

May play a role in apoptosis (PubMed:28688764, PubMed:19969290).
Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727).
Involved in dental enamel formation (PubMed:30506946).

Biological Process

Biological Process amelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane
Cytoplasm
Cytoplasm, perinuclear region

Involvement in disease

Amelogenesis imperfecta 3C (AI3C):
An autosomal recessive form of amelogenesis imperfecta, a defect of enamel formation. AI3C is characterized by generalized enamel hypocalcification affecting primary and secondary dentition. The surface of the enamel is rough and often stained. After eruption, the occlusal enamel on the molars disappears due to attrition, leaving a ring of intact enamel remaining on the sides.

Topology

Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-430

PTM

Phosphorylated in vitro by OXSR1 (PubMed:16389068).
Phosphorylated by STK39 (PubMed:16530727).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

RELT Matched Antibody Pair (985) (CAT#: APMAB-985LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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