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Mouse Anti-RELT Recombinant Antibody (3F8) (CBMAB-A9303-LY)

The product is antibody recognizes TNFRSF19L. The antibody 3F8 immunoassay techniques such as: WB, ELISA.
See all RELT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TNFRSF19L (NP_116260, 26 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RELT, TNF Receptor
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq]
Entrez Gene ID
84957
UniProt ID
Q969Z4
Alternative Names
FLJ14993; TNFRSF19L
Function
May play a role in apoptosis (PubMed:28688764, PubMed:19969290).
Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727).
Involved in dental enamel formation (PubMed:30506946).
Biological Process
Biological Process amelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Cytoplasm, perinuclear region
Involvement in disease
Amelogenesis imperfecta 3C (AI3C):
An autosomal recessive form of amelogenesis imperfecta, a defect of enamel formation. AI3C is characterized by generalized enamel hypocalcification affecting primary and secondary dentition. The surface of the enamel is rough and often stained. After eruption, the occlusal enamel on the molars disappears due to attrition, leaving a ring of intact enamel remaining on the sides.
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-430
PTM
Phosphorylated in vitro by OXSR1 (PubMed:16389068).
Phosphorylated by STK39 (PubMed:16530727).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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