Human Recombinant ROR1, Active protein, GST Tag (V2LY-0526-LY6587)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant ROR1, Active protein, GST Tag consist of Amino Acid: 429-end and predicts a molecular mass of 82 kDa.
Molecule Mass
82 kDa
Sequence
Amino Acid: 429-end
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Receptor Tyrosine Kinase Like Orphan Receptor 1
Function
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443).
Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
Biological Process
Biological Process astrocyte developmentIEA:Ensembl
Biological Process inner ear developmentISS:UniProtKB
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Cell projection, axon
Involvement in disease
Deafness, autosomal recessive, 108 (DFNB108):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Extracellular: 30-406
Helical: 407-427
Cytoplasmic: 428-937
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Alternative Versions

Human Recombinant ROR1 protein, GST Tag (CAT#: V2LY-0526-LY6580)

Human Recombinant ROR1 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY6581)

Human Recombinant ROR1 protein, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY6582)

Human Recombinant ROR1 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY6583)

Human Recombinant ROR1 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY6584)

Human Recombinant ROR1 protein, ECD, His Tag (CAT#: V2LY-0526-LY6585)

Human Recombinant ROR1 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY6586)

Human Recombinant ROR1 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY6588)

Human Recombinant ROR1 protein, hFc Tag (CAT#: V2LY-0526-LY6589)

Human Recombinant ROR1 protein, PE Conjugated, His Tag (CAT#: V2LY-0526-LY6590)

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Human Recombinant ROR1 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY6586)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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