Human Recombinant ROR1 protein, PE Conjugated, His Tag (V2LY-0526-LY6590)

Name: Human Recombinant ROR1 protein, PE Conjugated, His Tag
SKU: V2LY-0526-LY6590
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ROR1 protein, PE Conjugated, His Tag consist of Amino Acid: 1-403 and predicts a molecular mass of 45.3 kDa.

Molecule Mass

45.3 kDa

Conjugates

Sequence

Amino Acid: 1-403

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Twelve months from date of receipt at -20°C to -70°C in lyophilized form and 3 months at -70°C under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Receptor Tyrosine Kinase Like Orphan Receptor 1

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443).
Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).

Biological Process

Biological Process astrocyte developmentIEA:Ensembl
Biological Process inner ear developmentISS:UniProtKB
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane
Cell projection, axon

Involvement in disease

Deafness, autosomal recessive, 108 (DFNB108):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Topology

Extracellular: 30-406
Helical: 407-427
Cytoplasmic: 428-937

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ROR1 protein, GST Tag (CAT#: V2LY-0526-LY6580)

Human Recombinant ROR1 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY6581)

Human Recombinant ROR1 protein, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY6582)

Human Recombinant ROR1 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY6583)

Human Recombinant ROR1 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY6584)

Human Recombinant ROR1 protein, ECD, His Tag (CAT#: V2LY-0526-LY6585)

Human Recombinant ROR1 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY6586)

Human Recombinant ROR1, Active protein, GST Tag (CAT#: V2LY-0526-LY6587)

Human Recombinant ROR1 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY6588)

Human Recombinant ROR1 protein, hFc Tag (CAT#: V2LY-0526-LY6589)

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Human Recombinant ROR1 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY6588)

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Human Recombinant ROR1 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY6584)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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