Human Recombinant SLC7A5 (Nanodisc) protein, His Tag (V2LY-0526-LY6868)

solute carrier family 7 member 5

The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591).
Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591).
May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity).
May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).
Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859).
When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).
Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417).
Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).
(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.

Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to glucose starvationIEA:Ensembl
Biological Process cellular response to L-arginineIEA:Ensembl
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process isoleucine transportIEA:Ensembl
Biological Process L-leucine import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process L-tryptophan transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process leucine import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process liver regenerationIEA:Ensembl
Biological Process negative regulation of autophagyIEA:Ensembl
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process neutral amino acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process odontogenesisIEA:Ensembl
Biological Process phenylalanine transportManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process positive regulation of glial cell proliferationIEA:Ensembl
Biological Process positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of interleukin-4 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of leucine import across plasma membraneIEA:Ensembl
Biological Process response to hyperoxiaIEA:Ensembl
Biological Process response to muscle activityIEA:Ensembl
Biological Process thyroid hormone transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process valine transportIEA:Ensembl
Biological Process xenobiotic transportManual Assertion Based On ExperimentIMP:ARUK-UCL

Apical cell membrane
Cell membrane
Lysosome membrane
Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058).
Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812).
Recruited to lysosomes by LAPTM4B (PubMed:25998567).
Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).