Human Recombinant TACI protein, hFc Tag (V2LY-0526-LY7046)

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Datasheet
SDS
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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
hFc Tag
Protein Construction
This product is Human Recombinant TACI protein, hFc Tag consist of Amino Acid: 2-166 and predicts a molecular mass of 45.3 kDa.
Molecule Mass
45.3 kDa
Verified
HPLC
Sequence
Amino Acid: 2-166
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥90% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.
Endotoxin
<5 EU/mg protein.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TNFRSF13B Gene(Protein Coding) TNF Receptor Superfamily Member 13B
Function
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process B cell homeostasis Source:GO_Central1 Publication
Biological Process cell surface receptor signaling pathway Source:ProtInc1 Publication
Biological Process hematopoietic progenitor cell differentiation Source:GO_Central1 Publication
Biological Process negative regulation of B cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Involvement in disease
Immunodeficiency, common variable, 2 (CVID2):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Immunoglobulin A deficiency 2 (IGAD2):
Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
Topology
Extracellular: 1-165
Helical: 166-186
Cytoplasmic: 187-293
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TACI protein, ECD, hFc Tag (CAT#: V2LY-0526-LY7044)

Human Recombinant TACI protein, ECD, His Tag (CAT#: V2LY-0526-LY7045)

Cynomolgus Recombinant TNFRSF13B protein, His Tag (CAT#: V2LY-0526-LY1649)

TNFRSF13B Matched Antibody Pair (1218) (CAT#: APMAB-1218LY)

Antibody Pairs

TNFRSF13B Matched Antibody Pair (1218) (CAT#: APMAB-1218LY)

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Isotype control

For research use only. Not intended for any clinical use.

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