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TNFRSF13B

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF13B Gene(Protein Coding) TNF Receptor Superfamily Member 13B
Function
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process B cell homeostasis Source:GO_Central1 Publication
Biological Process cell surface receptor signaling pathway Source:ProtInc1 Publication
Biological Process hematopoietic progenitor cell differentiation Source:GO_Central1 Publication
Biological Process negative regulation of B cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Involvement in disease
Immunodeficiency, common variable, 2 (CVID2):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Immunoglobulin A deficiency 2 (IGAD2):
Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
Topology
Extracellular: 1-165
Helical: 166-186
Cytoplasmic: 187-293

Anti-TNFRSF13B antibodies

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Rat Anti-TNFRSF13B Recombinant Antibody (CBYJT-3717) (CBMAB-T3097-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3717
Application*: F

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3716) (CBMAB-T3096-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3716
Application*: WB, IH, EC

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3715) (CBMAB-T3095-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3715
Application*: F, MC

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3714) (CBMAB-T3094-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3714
Application*: IH, N, WB

Rabbit Anti-TNFRSF13B Recombinant Antibody (CBYJT-3713) (CBMAB-T3093-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3713
Application*: E

Mouse Anti-TNFRSF13B Recombinant Antibody (CBFYC-0235) (CBMAB-C0264-FY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0235
Application*: F

Rat Anti-Tnfrsf13b Recombinant Antibody (CBYJT-3731) (CBMAB-T3111-YJ)

Datasheet SDS
Target: Tnfrsf13b
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3731
Application*: WB, F, MC

Rat Anti-Tnfrsf13b Recombinant Antibody (CBYJT-3730) (CBMAB-T3110-YJ)

Datasheet SDS
Target: Tnfrsf13b
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3730
Application*: F, P, FN

Rat Anti-Tnfrsf13b Recombinant Antibody (CBYJT-3728) (CBMAB-T3108-YJ)

Datasheet SDS
Target: Tnfrsf13b
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3728
Application*: WB

Rat Anti-Tnfrsf13b Recombinant Antibody (CBYJT-3727) (CBMAB-T3107-YJ)

Datasheet SDS
Target: Tnfrsf13b
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3727
Application*: WB, F, MC, EC

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3726) (CBMAB-T3106-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3726
Application*: WB, C, N

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3725) (CBMAB-T3105-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3725
Application*: IH, N, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3724) (CBMAB-T3104-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3724
Application*: E, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3723) (CBMAB-T3103-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3723
Application*: E, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3722) (CBMAB-T3102-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3722
Application*: E, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3721) (CBMAB-T3101-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3721
Application*: E, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3720) (CBMAB-T3100-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3720
Application*: E, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3719) (CBMAB-T3099-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3719
Application*: E, WB

Mouse Anti-TNFRSF13B Recombinant Antibody (CBYJT-3718) (CBMAB-T3098-YJ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3718
Application*: E, WB

Rat Anti-TNFRSF13B Recombinant Antibody (8F10) (CBMAB-C9174-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 8F10
Application*: F

Mouse Anti-TNFRSF13B Recombinant Antibody (CBXC-2372) (CBMAB-C3662-CQ)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2372
Application*: F

Mouse Anti-TNFRSF13B Recombinant Antibody (11H3) (CBMAB-C0236-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11H3
Application*: C, FN

Rat Anti-TNFRSF13B Recombinant Antibody (1A1) (CBMAB-C0462-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A1
Application*: F

Rat Anti-TNFRSF13B Recombinant Antibody (CBYY-C0705) (CBMAB-C2087-YY)

Datasheet SDS
Target: TNFRSF13B
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0705
Application*: F

Mouse Anti-TNFRSF13B Recombinant Antibody (1E1) (CBMAB-A9265-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E1
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (3E3) (CBMAB-A9266-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E3
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1E12) (CBMAB-A9267-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E12
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1B5) (CBMAB-A9268-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B5
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1C4) (CBMAB-A9269-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C4
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1C9) (CBMAB-A9270-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C9
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1D5) (CBMAB-A9271-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D5
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1F4) (CBMAB-A9272-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F4
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1G1) (CBMAB-A9273-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G1
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1G11) (CBMAB-A9274-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G11
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (1H5) (CBMAB-A9275-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1H5
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (2C3) (CBMAB-A9276-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C3
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (2F6) (CBMAB-A9277-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F6
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (2H5) (CBMAB-A9278-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H5
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (3H4) (CBMAB-A9279-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H4
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (4A9) (CBMAB-A9280-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4A9
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (4C4) (CBMAB-A9281-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C4
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (4G1) (CBMAB-A9282-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4G1
Application*: WB, E

Mouse Anti-TNFRSF13B Recombinant Antibody (4G4) (CBMAB-A9283-LY)

Datasheet SDS
Target: TNFRSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4G4
Application*: WB, E

TNFRSF13B Matched Antibody Pair (1218) (APMAB-1218LY)

Datasheet SDS
Target: TNFRSF13B
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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