Human Recombinant TPX2 protein, His Tag (V2LY-0526-LY7345)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764).
TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940).
At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule nucleation Source:CACAO1 Publication
Biological Process mitotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerization Source:CACAO1 Publication
Biological Process regulation of mitotic spindle organization Source:UniProtKBBy Similarity
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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