TPX2

TPX2 (TPX2, Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Uterine Corpus Endometrial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.
Full Name
TPX2 Gene(Protein Coding) TPX2, Microtubule Nucleation Factor
Function
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764).
Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764).
TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940).
At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Biological Process
Biological Process activation of protein kinase activity Source:UniProtKB1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule nucleation Source:CACAO1 Publication
Biological Process mitotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerization Source:CACAO1 Publication
Biological Process regulation of mitotic spindle organization Source:UniProtKBBy Similarity
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
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Anti-TPX2 antibodies

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Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4447) (CBMAB-T3944-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4447
Application*: F, IC, IP, WB
Datasheet SDS

Rabbit Anti-TPX2 Recombinant Antibody (D9Y1V) (CBMAB-CP2838-LY)

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Target: TPX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D9Y1V
Application*: WB, IF (IC)
Datasheet SDS

Rabbit Anti-TPX2 Recombinant Antibody (D2R5C) (CBMAB-CP2837-LY)

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Target: TPX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D2R5C
Application*: WB, IP, IF (IC)
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (3H10-F8-D7) (CBMAB-Z0425-LY)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 3H10-F8-D7
Application*: WB
Datasheet SDS

Rabbit Anti-TPX2 Recombinant Antibody (CBYJT-4453) (CBMAB-T3953-YJ)

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Target: TPX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJT-4453
Application*: WB, IF
Datasheet SDS

Rabbit Anti-TPX2 Recombinant Antibody (CBYJT-4452) (CBMAB-T3952-YJ)

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Target: TPX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJT-4452
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4451) (CBMAB-T3951-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-4451
Application*: WB, IH, IC, IF, IP, P
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4450) (CBMAB-T3948-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-4450
Application*: E, WB
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4449) (CBMAB-T3947-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-4449
Application*: E, WB
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4448) (CBMAB-T3946-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4448
Application*: P, WB
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4446) (CBMAB-T3943-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJT-4446
Application*: E, WB
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (3164C6a) (CBMAB-T3942-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3164C6a
Application*: DB, IC, IP, WB, F
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (18D5) (CBMAB-T3940-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 18D5
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4444) (CBMAB-T3939-YJ)

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Target: TPX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4444
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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