TPX2

TPX2 (TPX2, Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Uterine Corpus Endometrial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.

TPX2 Gene(Protein Coding) TPX2, Microtubule Nucleation Factor

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764).
Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764).
TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940).
At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Biological Process activation of protein kinase activity Source:UniProtKB1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule nucleation Source:CACAO1 Publication
Biological Process mitotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerization Source:CACAO1 Publication
Biological Process regulation of mitotic spindle organization Source:UniProtKBBy Similarity

Nucleus
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.