Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4448) (CBMAB-T3946-YJ)

Name: Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4448)
SKU: CBMAB-T3946-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4448

Application

IHC-P, WB

Immunogen

Recombinant human TPX2

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TPX2 Gene(Protein Coding) TPX2, Microtubule Nucleation Factor

Introduction

TPX2 (TPX2, Microtubule Nucleation Factor) is a Protein Coding gene. Diseases related to TPX2 include Uterine Corpus Endometrial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to TPX2 include GTP binding and protein kinase binding.

Entrez Gene ID

22974

UniProt ID

Q9ULW0

Alternative Names

TPX2, Microtubule Nucleation Factor; Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2; Hepatocellular Carcinoma-Associated Antigen 519; Hepatocellular Carcinoma-Associated Antigen 90; Protein Fls353; C20orf1; C20orf2; HCA519; DIL-2; P100; DIL2; Restricted Expression Proliferation Associated Protein 100; Restricted Expression Proliferation-Associated Protein 100

Function

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764).
Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764).
TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940).
At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Biological Process

Biological Process activation of protein kinase activity Source:UniProtKB1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule nucleation Source:CACAO1 Publication
Biological Process mitotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerization Source:CACAO1 Publication
Biological Process regulation of mitotic spindle organization Source:UniProtKBBy Similarity

Cellular Location

Nucleus
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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