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Mouse Anti-TPX2 Recombinant Antibody (CBYJT-4444) (CBMAB-T3939-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TPX2 (TPX2, Microtubule Nucleation Factor). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TPX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4444
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-531 from human TPX2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-531

Target

Full Name
TPX2 Gene(Protein Coding) TPX2, Microtubule Nucleation Factor
Introduction
TPX2 (TPX2, Microtubule Nucleation Factor) is a Protein Coding gene. Diseases related to TPX2 include Uterine Corpus Endometrial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to TPX2 include GTP binding and protein kinase binding.
Entrez Gene ID
22974
UniProt ID
Q9ULW0
Alternative Names
TPX2, Microtubule Nucleation Factor; Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2; Hepatocellular Carcinoma-Associated Antigen 519; Hepatocellular Carcinoma-Associated Antigen 90; Protein Fls353; C20orf1; C20orf2; HCA519; DIL-2; P100; DIL2; Restricted Expression Proliferation Associated Protein 100; Restricted Expression Proliferation-Associated Protein 100
Function
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764).
Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764).
TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940).
At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Biological Process
Biological Process activation of protein kinase activity Source:UniProtKB1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule nucleation Source:CACAO1 Publication
Biological Process mitotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerization Source:CACAO1 Publication
Biological Process regulation of mitotic spindle organization Source:UniProtKBBy Similarity
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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