Human Recombinant YWHAZ protein, His Tag (V2LY-0526-LY1836)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396).
Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396).
Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396).
Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763).
In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Biological Process ERK1 and ERK2 cascade Source:Ensembl
Biological Process establishment of Golgi localization Source:UniProtKB1 Publication
Biological Process Golgi reassembly Source:UniProtKB1 Publication
Biological Process lung development Source:Ensembl
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of ERK1 and ERK2 cascade Source:UniProtKB1 Publication
Biological Process regulation of synapse maturation Source:SynGO2 Publications
Biological Process respiratory system process Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process synaptic target recognition Source:Ensembl
Biological Process tube formation Source:Ensembl
Melanosome
Located to stage I to stage IV melanosomes.
Phosphorylation on Thr-232; inhibits binding of RAF1 (PubMed:9360956).
Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).
Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant YWHAZ protein (CAT#: V2LY-0526-LY1834)
Mouse Recombinant YWHAZ protein, His Tag (CAT#: V2LY-0526-LY7748)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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