Human RERE ELISA Kit (V2LY-0626-LY3946)

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Tested Data
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Basic Information

Sensitivity
0.104 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
172.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
arginine-glutamic acid dipeptide (RE) repeats
Function
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Biological Process
Biological Process branching morphogenesis of a nerveIEA:Ensembl
Biological Process cerebellar granule cell precursor proliferationIEA:Ensembl
Biological Process cerebellar Purkinje cell layer maturationIEA:Ensembl
Biological Process chromatin remodelingIEA:Ensembl
Biological Process dendrite morphogenesisIEA:Ensembl
Biological Process radial glia guided migration of Purkinje cellIEA:Ensembl
Cellular Location
Nucleus
Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
Involvement in disease
Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH):
An autosomal dominant syndrome characterized by developmental delay, intellectual disability, brain anomalies, and neurological abnormalities including seizures, hypotonia, and behavioral problems such as autism spectrum disorders. Brain anomalies include abnormalities and/or thinning of the corpus callosum, diminished white matter volume, abnormal cerebellar vermis, and ventriculomegaly. Congenital defects of the eye, heart and genitourinary system are present in half of the patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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