Human SELPLG ELISA Kit (V2LY-0626-LY5143)

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Tested Data
Datasheet
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Basic Information

Sensitivity
1.55 U/mL
Detection Range
3-900 U/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
43.2 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Selectin P Ligand
Function
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
(Microbial infection) Acts as a receptor for enterovirus 71.
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to interleukin-6Manual Assertion Based On ExperimentIDA:MGI
Biological Process hemopoiesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process leukocyte adhesive activationISS:UniProtKB
Biological Process leukocyte migrationManual Assertion Based On ExperimentIDA:CAFA
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIDA:CAFA
Cellular Location
Membrane
Topology
Extracellular: 18-320
Helical: 321-341
Cytoplasmic: 342-412
PTM
Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SELPLG protein, His & hFc Tag (CAT#: V2LY-0526-LY6367)

Human Recombinant SELPLG protein, His Tag (CAT#: V2LY-0526-LY6368)

Human Recombinant SELPLG protein, Fc Tag (CAT#: V2LY-0526-LY6369)

Mouse Recombinant SELPLG protein (CAT#: V2LY-0526-LY8814)

Mouse Recombinant SELPLG protein, hFc Tag (CAT#: V2LY-0526-LY8815)

Related Products

Mouse Anti-SELPLG Recombinant Antibody (3E2.25.5 PL1) (CAT#: CBMAB-C1111-LY)

Rat Anti-SELPLG Recombinant Antibody (HECA-452) (CAT#: CBMAB-C0698-CQ)

Human Recombinant SELPLG protein, Fc Tag (CAT#: V2LY-0526-LY6369)

Mouse Anti-SELPLG Recombinant Antibody (12K53) (CAT#: CBMAB-C4260-CN)

Mouse Recombinant SELPLG protein, hFc Tag (CAT#: V2LY-0526-LY8815)

Mouse Anti-SELPLG Recombinant Antibody (1.BB.238) (CAT#: CBMAB-C1962-LY)

Mouse Anti-SELPLG Recombinant Antibody (CBXS-0196) (CAT#: CBMAB-S3182-CQ)

Mouse Anti-SELPLG Recombinant Antibody (CBXS-0193) (CAT#: CBMAB-S3179-CQ)

Mouse Anti-SELPLG Recombinant Antibody (TB5) (CAT#: CBMAB-C12400-LY)

Mouse Anti-SELPLG Recombinant Antibody (10B835) (CAT#: CBMAB-C2269-LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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