Human TNFRSF1B ELISA Kit (V2LY-0626-LY5695)

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Basic Information

Sensitivity
0.011 ng/mL
Detection Range
0.02-3.8 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
48.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
TNFRSF1B Gene(Protein Coding) TNF Receptor Superfamily Member 1B
Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Biological Process
Biological Process aging Source:Ensembl
Biological Process aortic valve development Source:BHF-UCL
Biological Process cellular response to growth factor stimulus Source:Ensembl
Biological Process cellular response to lipopolysaccharide Source:BHF-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process glial cell-neuron signaling Source:ARUK-UCL
Biological Process immune response Source:Ensembl
Biological Process inflammatory response Source:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage Source:GO_Central1 Publication
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process negative regulation of cell death Source:ARUK-UCL
Biological Process negative regulation of extracellular matrix constituent secretion Source:BHF-UCL
Biological Process negative regulation of neuroinflammatory response Source:ARUK-UCL
Biological Process negative regulation of neuron death Source:ARUK-UCL
Biological Process positive regulation of apoptotic process involved in morphogenesis Source:BHF-UCL
Biological Process positive regulation of membrane protein ectodomain proteolysis Source:BHF-UCL1 Publication
Biological Process positive regulation of myelination Source:ARUK-UCL
Biological Process positive regulation of oligodendrocyte differentiation Source:ARUK-UCL
Biological Process pulmonary valve development Source:BHF-UCL
Biological Process regulation of cytokine production involved in immune response Source:ARUK-UCL
Biological Process regulation of myelination Source:ARUK-UCL
Biological Process regulation of neuroinflammatory response Source:ARUK-UCL
Biological Process regulation of RNA biosynthetic process Source:ARUK-UCL
Biological Process regulation of T cell cytokine production Source:ARUK-UCL
Biological Process regulation of T cell proliferation Source:ARUK-UCL
Biological Process RNA destabilization Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:ARUK-UCL1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Tumor necrosis factor-binding protein 2
Secreted
Topology
Extracellular: 23-257
Helical: 258-287
Cytoplasmic: 288-461
PTM
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
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Alternative Versions

Cynomolgus, Rhesus Recombinant CD120B protein, hFc Tag (CAT#: V2LY-0526-LY1745)

Cynomolgus, Rhesus Recombinant CD120B protein, His Tag (CAT#: V2LY-0526-LY1746)

Human Recombinant TNFRSF1B (196 Met/Arg) protein, His Tag (CAT#: V2LY-0526-LY7306)

Human Recombinant TNFRSF1B (196 Met/Arg) protein, His Tag-1 (CAT#: V2LY-0526-LY7307)

Human Recombinant TNFRSF1B protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY7308)

Human Recombinant TNFRSF1B protein, ECD, His & hFc Tag (CAT#: V2LY-0526-LY7309)

Human Recombinant TNFRSF1B protein, ECD, His Tag (CAT#: V2LY-0526-LY7310)

Human Recombinant TNFRSF1B protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY7311)

Mouse Recombinant TNFRSF1B protein, hFc Tag (CAT#: V2LY-0526-LY8998)

Mouse Recombinant TNFRSF1B protein, His Tag (CAT#: V2LY-0526-LY8999)

Antibody Pairs

TNFRSF1B Matched Antibody Pair (1232) (CAT#: APMAB-1232LY)

TNFRSF1B Matched Antibody Pair (1233) (CAT#: APMAB-1233LY)

TNFRSF1B Matched Antibody Pair (1234) (CAT#: APMAB-1234LY)

Related Products

Hamster Anti-TNFRSF1B Recombinant Antibody (TR75-54.7) (CAT#: CBMAB-C12568-LY)

Recombinant Rat Anti-TNFRSF1B Antibody (CBHb008) (CAT#: CBMAB-Hb1188-LY)

Mouse Anti-TNFRSF1B Recombinant Antibody (CBYJT-3813) (CAT#: CBMAB-T3201-YJ)

Cynomolgus, Rhesus Recombinant CD120B protein, hFc Tag (CAT#: V2LY-0526-LY1745)

Mouse Anti-TNFRSF1B Recombinant Antibody (CBFYC-3174) (CAT#: CBMAB-C3251-FY)

Hamster Anti-Tnfrsf1b Recombinant Antibody (CBYJT-3828) (CAT#: CBMAB-T3219-YJ)

Mouse Anti-TNFRSF1B Recombinant Antibody (CBFYA-0073) (CAT#: CBMAB-X0104-FY)

Mouse Anti-TNFRSF1B Recombinant Antibody (CBXC-3069) (CAT#: CBMAB-C4626-CQ)

Mouse Anti-TNFRSF1B Monoclonal Antibody (MR2-1) (CAT#: CBMAB-1649-YC)

Mouse Anti-TNFRSF1B Recombinant Antibody (CBFYA-0080) (CAT#: CBMAB-X0114-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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