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TNFRSF1B

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF1B Gene(Protein Coding) TNF Receptor Superfamily Member 1B
Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Biological Process
Biological Process aging Source:Ensembl
Biological Process aortic valve development Source:BHF-UCL
Biological Process cellular response to growth factor stimulus Source:Ensembl
Biological Process cellular response to lipopolysaccharide Source:BHF-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process glial cell-neuron signaling Source:ARUK-UCL
Biological Process immune response Source:Ensembl
Biological Process inflammatory response Source:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage Source:GO_Central1 Publication
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process negative regulation of cell death Source:ARUK-UCL
Biological Process negative regulation of extracellular matrix constituent secretion Source:BHF-UCL
Biological Process negative regulation of neuroinflammatory response Source:ARUK-UCL
Biological Process negative regulation of neuron death Source:ARUK-UCL
Biological Process positive regulation of apoptotic process involved in morphogenesis Source:BHF-UCL
Biological Process positive regulation of membrane protein ectodomain proteolysis Source:BHF-UCL1 Publication
Biological Process positive regulation of myelination Source:ARUK-UCL
Biological Process positive regulation of oligodendrocyte differentiation Source:ARUK-UCL
Biological Process pulmonary valve development Source:BHF-UCL
Biological Process regulation of cytokine production involved in immune response Source:ARUK-UCL
Biological Process regulation of myelination Source:ARUK-UCL
Biological Process regulation of neuroinflammatory response Source:ARUK-UCL
Biological Process regulation of RNA biosynthetic process Source:ARUK-UCL
Biological Process regulation of T cell cytokine production Source:ARUK-UCL
Biological Process regulation of T cell proliferation Source:ARUK-UCL
Biological Process RNA destabilization Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:ARUK-UCL1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Tumor necrosis factor-binding protein 2
Secreted
Topology
Extracellular: 23-257
Helical: 258-287
Cytoplasmic: 288-461
PTM
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.

Anti-TNFRSF1B antibodies

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Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: MR2-1
Application*: F, IC, IF, IP, WB
Target: TNFRSF1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR1653
Application*: F, IC, P, IP, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXC-3069
Application*: IP, IF, E, FN, F
Target: TNFRSF1B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: HM102
Application*: IP, C, F
Target: Tnfrsf1b
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3825
Application*: E, F, IP, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Monkey
Clone: CBYJT-3824
Application*: E
Target: TNFRSF1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBYJT-3823
Application*: E
Target: TNFRSF1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-3822
Application*: WB, IP, P, IC, F
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3810
Application*: E, WB, IH
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3812
Application*: WB, N, EC
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3813
Application*: N, IC
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3814
Application*: F, MC
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3815
Application*: C, IA, FN, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3816
Application*: WB, IH
Target: TNFRSF1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3817
Application*: E
Target: TNFRSF1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3818
Application*: N
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYJT-3819
Application*: E, WB, IP, IH, F
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-3820
Application*: E, IP, F, IF
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-3821
Application*: E, F, IC, IH, IP, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYA-0080
Application*: F, FN, IA, IF, IP
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0084
Application*: N, F
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: utr1
Application*: IH, IP, WB, FC, P
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYA-0073
Application*: F, C, FN, IA, IF, IP, WB
Target: TNFRSF1B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0007
Application*: F, C, FN, IA, IP, WB
Target: Tnfrsf1b
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3828
Application*: E, F, IF, IP
Target: Tnfrsf1b
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3827
Application*: WB, F, E, IP, MC
Target: Tnfrsf1b
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3826
Application*: IP, IH, F
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G7A02
Application*: F
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2/220
Application*: C, E, FN, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 80M2
Application*: IP, IC/IF, E, FN, F
Target: TNFRSF1B
Host: Hamster
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: TR75-89
Application*: F
Target: TNFRSF1B
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: TR75-32.4
Application*: F
Target: TNFRSF1B
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: TR75-54
Application*: E, F
Target: TNFRSF1B
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: TR75-54.7
Application*: F
Target: TNFRSF1B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb008
Application*: FC, IHC-F, FuncS, Immuno assays, IP, WB
Target: TNFRSF1B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb009
Application*: FC, IHC-F, FuncS, Immuno assays, IP, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBHb118
Application*: FC, IHC-F, FuncS, Immuno assays, IF, IP, WB
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBHb128
Application*: FC, FuncS, Immuno assays, IF, IP
Target: TNFRSF1B
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: A1434
Application*: Block, FC, IP, WB
Target: TNFRSF1B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJC-2445
Application*: WB, IP, E, FN, C
Target: TNFRSF1B
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-2446
Application*: F
Target: TNFRSF1B
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0873
Application*: F
Target: TNFRSF1B
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0756
Application*: F
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4526
Application*: E
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4273
Application*: WB, E, N
Target: TNFRSF1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-3174
Application*: C, FN, WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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