Human TOP2B ELISA Kit (V2LY-0626-LY4503)

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Tested Data
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Basic Information

Sensitivity
0.005 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
183.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
DNA Topoisomerase II Beta
Function
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.
Biological Process
Biological Process axonogenesis Source:Ensembl
Biological Process B cell differentiation Source:UniProtKB2 Publications
Biological Process DNA topological change Source:UniProtKB1 Publication
Biological Process forebrain development Source:Ensembl
Biological Process neuron migration Source:Ensembl
Biological Process positive regulation of single stranded viral RNA replication via double stranded DNA intermediate Source:UniProtKB1 Publication
Biological Process resolution of meiotic recombination intermediates Source:GO_Central1 Publication
Biological Process sister chromatid segregation Source:GO_Central1 Publication
Cellular Location
Nucleus, nucleolus
Nucleus, nucleoplasm
Nucleus
Involvement in disease
B-cell immunodeficiency, distal limb anomalies, and urogenital malformations (BILU):
An autosomal dominant disorder characterized by humoral immunodeficiency with undetectable B cells, distal limb anomalies, dysmorphic facial features, and urogenital malformations.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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