Sign in or Register   Sign in or Register
  |  

HUS1 Matched Antibody Pair (579) (APMAB-579LY)

This antibody pair set can be used for detecting and quantifying protein level of human HUS1.
See all HUS1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HUS1 polyclonal antibody, 100 ug
Detection Antibody
Anti-HUS1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Alternative Names
HUS1 Checkpoint Clamp Component; Hus1+-Like Protein; HHUS1; HUS1 (S. Pombe) Checkpoint Homolog; HUS1 Checkpoint Homolog (S. Pombe); HUS1 Checkpoint Homolog; Checkpoint Protein HUS1;
Entrez Gene ID
3364
UniProt ID
O60921

Mascarenhas dos Santos, A. C., Julian, A. T., & Pombert, J. F. (2022). The Rad9–Rad1–Hus1 DNA Repair clamp is found in microsporidia. Genome Biology and Evolution, 14(4), evac053.

Hwang, B. J., Gonzales, R., Corzine, S., Stenson, E., Pidugu, L., & Lu, A. L. (2022). DNA binding by the Rad9A subunit of the Rad9-Rad1-Hus1 complex. Plos one, 17(8), e0272645.

Hashimoto, H., Hara, K., & Hishiki, A. (2022). Structural basis for molecular interactions on the eukaryotic DNA sliding clamps PCNA and RAD9-RAD1-HUS1. The Journal of Biochemistry, 172(4), 189-196.

Ren, K., Yu, Y., Wang, X., Liu, H., & Zhao, J. (2021). MiR-340-3p-HUS1 axis suppresses proliferation and migration in lung adenocarcinoma cells. Life Sciences, 274, 119330.

Tan, J., Wang, X., Hwang, B. J., Gonzales, R., Konen, O., Lan, L., & Lu, A. L. (2020). An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres. Aging (Albany NY), 12(18), 17761.

Zhou, Z. Q., Zhao, J. J., Chen, C. L., Liu, Y., Zeng, J. X., Wu, Z. R., ... & Xia, J. C. (2019). HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma. Molecular Carcinogenesis, 58(1), 76-87.

Damasceno, J. D., Obonaga, R., Silva, G. L., Reis-Cunha, J. L., Duncan, S. M., Bartholomeu, D. C., ... & Tosi, L. R. (2018). Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9–1–1 complex in the maintenance of the plastic genome of Leishmania. Nucleic Acids Research, 46(22), 11835-11846.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used HUS1 Matched Antibody Pair (579)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare