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IFI16 Matched Antibody Pair (588) (APMAB-588LY)

This antibody pair set can be used for detecting and quantifying protein level of human IFI16.
See all IFI16 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IFI16 polyclonal antibody, 100 ug
Detection Antibody
Anti-IFI16 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Alternative Names
Interferon Gamma Inducible Protein 16
Entrez Gene ID
3428
UniProt ID
Q16666

Barrientos, M. O., Cruz, Á. A., Teixeira, H. M., dos Santos Silva, H., Gomes-Filho, I. S., Trindade, S. C., ... & Oliveira, T. T. M. C. (2023). Variants in interferon gamma inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) genes that modulate inflammatory response are associated with periodontitis. Archives of Oral Biology, 147, 105640.

Borucka, J., Sterzyńska, K., Kaźmierczak, D., Świerczewska, M., Nowacka, M., Wojtowicz, K., ... & Januchowski, R. (2022). The significance of interferon gamma inducible protein 16 (IFI16) expression in drug resistant ovarian cancer cell lines. Biomedicine & Pharmacotherapy, 150, 113036.

Pucinelli, C. M., Lima, R. B., Almeida, L. K., Lucisano, M. P., Córdoba, A. Z., Marchesan, J. T., ... & da Silva, R. A. (2022). Interferon‐gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild‐type mice. International Endodontic Journal, 55(10), 1042-1052.

Ong, L. T., Lee, W. C., Ma, S., Oguz, G., Niu, Z., Bao, Y., ... & Yu, Q. (2022). IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer. Proceedings of the National Academy of Sciences, 119(31), e2201376119.

Xu, H., Li, X., Rousseau, B. A., Akinyemi, I. A., Frey, T. R., Zhou, K., ... & Bhaduri-McIntosh, S. (2022). IFI16 partners with KAP1 to maintain Epstein-Barr virus latency. Journal of Virology, 96(17), e01028-22.

Griffante, G., Hewelt-Belka, W., Albano, C., Gugliesi, F., Pasquero, S., Castillo Pacheco, S. F., ... & Biolatti, M. (2022). IFI16 impacts metabolic reprogramming during human cytomegalovirus infection. Mbio, 13(3), e00435-22.

Lu, Y. Q., Wu, J., Wu, X. J., Ma, H., Ma, Y. X., Zhang, R., ... & Pan, X. B. (2021). Interferon gamma-inducible protein 16 of peripheral blood mononuclear cells may sense hepatitis B virus infection and regulate the antiviral immunity. Frontiers in Cellular and Infection Microbiology, 1143.

Piccaluga, P. P., Navari, M., Visani, A., Rigotti, F., Agostinelli, C., Righi, S., ... & Gibellini, D. (2019). Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma. Heliyon, 5(11).

Hurst, T. P., Aswad, A., Karamitros, T., Katzourakis, A., Smith, A. L., & Magiorkinis, G. (2019). Interferon-inducible protein 16 (IFI16) has a broad-spectrum binding ability against ssDNA targets: an evolutionary hypothesis for antiretroviral checkpoint. Frontiers in microbiology, 10, 1426.

Chen, H., He, G., Chen, Y., Zhang, X., & Wu, S. (2018). Differential activation of NLRP3, AIM2, and IFI16 inflammasomes in humans with acute and chronic hepatitis B. Viral immunology, 31(9), 639-645.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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