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IL7R Matched Antibody Pair (639) (APMAB-639LY)

This antibody pair set can be used for detecting and quantifying protein level of human IL7R.
See all IL7R antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IL7R polyclonal antibody, 100 ug
Detection Antibody
Anti-IL7R Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
Alternative Names
Interleukin 7 Receptor
Entrez Gene ID
3575
UniProt ID
P16871

Lee, K. Y., Ho, S. C., Sun, W. L., Feng, P. H., Lin, C. W., Chen, K. Y., ... & Wu, S. M. (2022). Lnc-IL7R alleviates PM2. 5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease. Cell Biology and Toxicology, 38(6), 1097-1120.

Oliveira, M. L., Veloso, A., Garcia, E. G., Iyer, S., Pereira, C., Barreto, V. M., ... & Barata, J. T. (2022). Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia. Leukemia, 36(6), 1533-1540.

Wang, X., Chang, S., Wang, T., Wu, R., Huang, Z., Sun, J., ... & Mao, Y. (2022). IL7R is correlated with immune cell infiltration in the tumor microenvironment of lung adenocarcinoma. Frontiers in pharmacology, 13, 857289.

Berna, R., Mitra, N., Lou, C., Wan, J., Hoffstad, O., Wubbenhorst, B., ... & Margolis, D. J. (2021). Thymic stromal lymphopoietin and IL7R variants are associated with persistent atopic dermatitis. The Journal of investigative dermatology, 141(2), 446.

Abdelrasoul, H., Vadakumchery, A., Werner, M., Lenk, L., Khadour, A., Young, M., ... & Jumaa, H. (2020). Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11(1), 3194.

Kim, R., Boissel, N., Touzart, A., Leguay, T., Thonier, F., Thomas, X., ... & GRAALL group. (2020). Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation. Leukemia, 34(7), 1730-1740.

Al-Mossawi, H., Yager, N., Taylor, C. A., Lau, E., Danielli, S., de Wit, J., ... & Fairfax, B. P. (2019). Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nature Communications, 10(1), 4575.

Leung, G. A., Cool, T., Valencia, C. H., Worthington, A., Beaudin, A. E., & Forsberg, E. C. (2019). The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development. Development, 146(14), dev176180.

Alsadeq, A., Lenk, L., Vadakumchery, A., Cousins, A., Vokuhl, C., Khadour, A., ... & Jumaa, H. (2018). IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, The Journal of the American Society of Hematology, 132(15), 1614-1617.

Fan, Y., Nan, Y., Huang, J., Zhong, H., & Zhou, W. (2018). Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome in patients with cervical cancer. Bioscience reports, 38(3), BSR20180483.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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