IL7R Matched Antibody Pair (639) (APMAB-639LY)

Name: IL7R Matched Antibody Pair (639)
SKU: APMAB-639LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-IL7R polyclonal antibody, 100 ug

Detection Antibody

Anti-IL7R Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]

Alternative Names

Interleukin 7 Receptor

Entrez Gene ID

3575

UniProt ID

P16871

More Infomation

Lee, K. Y., Ho, S. C., Sun, W. L., Feng, P. H., Lin, C. W., Chen, K. Y., ... & Wu, S. M. (2022). Lnc-IL7R alleviates PM2. 5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease. Cell Biology and Toxicology, 38(6), 1097-1120.

Oliveira, M. L., Veloso, A., Garcia, E. G., Iyer, S., Pereira, C., Barreto, V. M., ... & Barata, J. T. (2022). Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia. Leukemia, 36(6), 1533-1540.

Wang, X., Chang, S., Wang, T., Wu, R., Huang, Z., Sun, J., ... & Mao, Y. (2022). IL7R is correlated with immune cell infiltration in the tumor microenvironment of lung adenocarcinoma. Frontiers in pharmacology, 13, 857289.

Berna, R., Mitra, N., Lou, C., Wan, J., Hoffstad, O., Wubbenhorst, B., ... & Margolis, D. J. (2021). Thymic stromal lymphopoietin and IL7R variants are associated with persistent atopic dermatitis. The Journal of investigative dermatology, 141(2), 446.

Abdelrasoul, H., Vadakumchery, A., Werner, M., Lenk, L., Khadour, A., Young, M., ... & Jumaa, H. (2020). Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11(1), 3194.

Kim, R., Boissel, N., Touzart, A., Leguay, T., Thonier, F., Thomas, X., ... & GRAALL group. (2020). Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation. Leukemia, 34(7), 1730-1740.

Al-Mossawi, H., Yager, N., Taylor, C. A., Lau, E., Danielli, S., de Wit, J., ... & Fairfax, B. P. (2019). Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nature Communications, 10(1), 4575.

Leung, G. A., Cool, T., Valencia, C. H., Worthington, A., Beaudin, A. E., & Forsberg, E. C. (2019). The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development. Development, 146(14), dev176180.

Alsadeq, A., Lenk, L., Vadakumchery, A., Cousins, A., Vokuhl, C., Khadour, A., ... & Jumaa, H. (2018). IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, The Journal of the American Society of Hematology, 132(15), 1614-1617.

Fan, Y., Nan, Y., Huang, J., Zhong, H., & Zhou, W. (2018). Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome in patients with cervical cancer. Bioscience reports, 38(3), BSR20180483.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CD127 protein, His Tag (CAT#: V2LY-0526-LY1580)

Cynomolgus Recombinant CD127 protein, His Tag-1 (CAT#: V2LY-0526-LY1581)

Human Recombinant IL7R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4956)

Human Recombinant IL7R protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4957)

Human Recombinant IL7R protein, ECD, His Tag (CAT#: V2LY-0526-LY4958)

Mouse Recombinant IL7R protein, His Tag (CAT#: V2LY-0526-LY8554)

Rat Recombinant IL7R protein, His Tag (CAT#: V2LY-0526-LY9485)

Rat Recombinant IL7R protein, Fc Tag (CAT#: V2LY-0526-LY9486)

Related Products

Mouse Anti-IL7R Recombinant Antibody (CBT2785) (CAT#: V2LY-0625-LY1144)

Human Anti-IL7R Recombinant Antibody (CBXC-0897) (CAT#: CBMAB-C2012-CQ)

Rat Anti-IL7R Recombinant Antibody (A7R34) (CAT#: CBMAB-C2995WJ)

Cynomolgus Recombinant CD127 protein, His Tag (CAT#: V2LY-0526-LY1580)

Rat Recombinant IL7R protein, His Tag (CAT#: V2LY-0526-LY9485)

Mouse Anti-IL7R Recombinant Antibody (CBYY-C1161) (CAT#: CBMAB-C2598-YY)

Human Recombinant IL7R protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4957)

Rat Anti-IL7R Recombinant Antibody (CBYY-I1432) (CAT#: CBMAB-I2602-YY)

Mouse Anti-IL7R Recombinant Antibody (RDR5) (CAT#: CBMAB-C11744-LY)

Rat Anti-IL7R (AA 145-235) Recombinant Antibody (CBYY-I0726) (CAT#: CBMAB-I1619-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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