ITPKB Matched Antibody Pair (653) (APMAB-653LY)

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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-ITPKB monoclonal antibody, 100 ug
Detection Antibody
Anti-ITPKB Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Alternative Names
Inositol-Trisphosphate 3-Kinase B
Entrez Gene ID
UniProt ID
More Infomation

Di Leva, F., Filosi, M., Oyston, L., Silvestri, E., Picard, A., Lavdas, A. A., ... & Corti, C. (2023). Increased Levels of the Parkinson’s Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status. International Journal of Molecular Sciences, 24(3), 1984.

Li, J., Zheng, C., Wang, M., Umano, A. D., Dai, Q., Zhang, C., ... & Pan, C. (2022). ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer. Oncogene, 41(8), 1114-1128.

Fang, H. S., Wang, C. C., Chao, C. Y., Fan, W. L., Su, S. C., & Wu, Y. R. (2022). Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan. Journal of the Formosan Medical Association, 121(3), 679-686.

Apicco, D. J., Shlevkov, E., Nezich, C. L., Tran, D. T., Guilmette, E., Nicholatos, J. W., ... & Hirst, W. D. (2021). The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release. Proceedings of the National Academy of Sciences, 118(1), e2006476118.

Almutairi, A., Wallace, J. G., Jaber, F., Alosaimi, M. F., Jones, J., Sallam, M. T., ... & Geha, R. S. (2020). Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. Journal of Allergy and Clinical Immunology, 145(6), 1696-1699.

Zhang, Y., Xu, C., Nan, Y., & Nan, S. (2020). Microglia-derived extracellular vesicles carrying miR-711 alleviate neurodegeneration in a murine Alzheimer’s disease model by binding to Itpkb. Frontiers in cell and developmental biology, 8, 566530.

Bäder, S., Glaubke, E., Grüb, S., Muhs, S., Wellbrock, J., Nalaskowski, M., ... & Windhorst, S. (2018). Effect of the actin-and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells. Biochemical Journal, 475(12), 2057-2071.

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For research use only. Not intended for any clinical use.

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