ITPKB

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

Full Name

Inositol-Trisphosphate 3-Kinase B

Function

Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.

Biological Process

Cell surface receptor signaling pathwayIEA:Ensembl
Cellular response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Common myeloid progenitor cell proliferationIEA:Ensembl
Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Inositol trisphosphate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
MAPK cascadeIEA:Ensembl
Myeloid cell homeostasisIEA:Ensembl
Negative regulation of myeloid cell differentiationIEA:Ensembl
Negative regulation of neutrophil apoptotic processIEA:Ensembl
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of alpha-beta T cell differentiationIEA:Ensembl
Positive regulation of Ras protein signal transductionIEA:Ensembl
Positive thymic T cell selectionIEA:Ensembl
Regulation of protein phosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm; Cytosol; Membrane; Nucleus